{"id":38174,"date":"2018-03-09T09:37:38","date_gmt":"2018-03-09T09:37:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/profilaxis-de-la-eich-en-el-trasplante-alogenico-de-medula-osea-mediante-deplecion-total-de-linfocitos-cd4-y-controlada-de-cd8-seguimiento-de-la-recuperacion-inmunologica\/"},"modified":"2018-03-09T09:37:38","modified_gmt":"2018-03-09T09:37:38","slug":"profilaxis-de-la-eich-en-el-trasplante-alogenico-de-medula-osea-mediante-deplecion-total-de-linfocitos-cd4-y-controlada-de-cd8-seguimiento-de-la-recuperacion-inmunologica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/cirugia-de-trasplantes\/profilaxis-de-la-eich-en-el-trasplante-alogenico-de-medula-osea-mediante-deplecion-total-de-linfocitos-cd4-y-controlada-de-cd8-seguimiento-de-la-recuperacion-inmunologica\/","title":{"rendered":"Profilaxis de la eich en el trasplante alogenico de medula osea mediante deplecion total de linfocitos cd4+ y controlada de cd8+.seguimiento de la recuperacion inmunologica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> David Gallardo Giralt <\/strong><\/h2>\n<p>Desde 1993 a 1997 se introdujo en este estudio a 29 pacientes receptores de un trasplante alogenico de alto riesgo de enfermedad del injerto contra el huesped (eich), seg\u00fan fueran: receptores de un trasplante alogenico de donante no emparentado (dne), o bien pacientes con lmc mayores de 30 a\u00f1os, y\/o con donante sensibilizado por embarazos o transfusiones previas. se practic\u00f3 una depleci\u00f3n total de linfocitos cd4+ y se separ\u00f3 un volumen que contuviera la cantidad deseada de linfocitos cd8+. Se decidi\u00f3 infundir una cantidad fija de 1&#215;10 linfocitos cd8+\/kg de receptor, y se hizo profilaxis con ciclosporina a, metotrexate en tanda corta y prednisona.  se incluyeron 9 pacientes: todos injertaron. Para los receptores de donante familiar, la tasa de eich estadios ii-iv fue de 40%, y para que los receptores de dne fue de 66,6%. La eich estadios iii-iv fue de 20% y 0% respectivamente. la alta incidencia de mortalidad de causa infecciosa hizo que se suprimiera la prednisona post-trasplante en una 2\u00aa experiencia, y se disminuyo la cantidad de linfocitos cd8+infundidos a la mitad.  se incluyeron 8 pacientes receptores de un trasplante de dne y 12 pacientes de hermano hla-identico. Todos los pacientes injeraron. Tasa de eich estadios ii-iv: 66,6% (tmo familiar), y 62,5%(dne) eich estadios iii-iv:16,7% y 37,5% respectivamente. Aquellos pacientes que recibieron un trasplante de hermano hla-identico, presentan una supervivencia libre de enfermedad del 81,8% a los tres de seguimiento. Recuperaci\u00f3n inmunologica: el numero total de linfocitos se normaliz\u00f3 a los tres meses post-tomi. Esta recuperaci\u00f3n vino dada por linfocitos t cd8+ y celulas nk. El aumento de linfocitos cd8+ se acompa\u00f1o de expresion de marcadores de activaci\u00f3n cd38 y hla-dr.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Profilaxis de la eich en el trasplante alogenico de medula osea mediante deplecion total de linfocitos cd4+ y controlada de cd8+.seguimiento de la recuperacion inmunologica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Profilaxis de la eich en el trasplante alogenico de medula osea mediante deplecion total de linfocitos cd4+ y controlada de cd8+.seguimiento de la recuperacion inmunologica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 David Gallardo Giralt <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Alberto Gra\u00f1ena Batista<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Torres g\u00f3mez <\/li>\n<li>benet Nomdedeu tobella (vocal)<\/li>\n<li>miquel Rutllant banyeres (vocal)<\/li>\n<li>joan Pera farregas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de David Gallardo Giralt Desde 1993 a 1997 se introdujo en este estudio a 29 pacientes receptores de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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