{"id":38175,"date":"2018-03-09T09:37:38","date_gmt":"2018-03-09T09:37:38","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/melatonina-en-la-diabetes-experimental-y-estres-oxidativo-inducidos-en-la-rata-por-la-administracion-de-estreptozotocina\/"},"modified":"2018-03-09T09:37:38","modified_gmt":"2018-03-09T09:37:38","slug":"melatonina-en-la-diabetes-experimental-y-estres-oxidativo-inducidos-en-la-rata-por-la-administracion-de-estreptozotocina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/melatonina-en-la-diabetes-experimental-y-estres-oxidativo-inducidos-en-la-rata-por-la-administracion-de-estreptozotocina\/","title":{"rendered":"Melatonina en la diabetes experimental y estr\u00e9s oxidativo inducidos en la rata por la administraci\u00f3n de estreptozotocina"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Vargas Fresno <\/strong><\/h2>\n<p>El presente trabajo muestra el efecto de dos dosis de melatonina (mel, 50 y 100 ug\/animad\u00eda s.C.) Durante 6 y 12 semanas, sobre la diabetes tipo i (iddm) inducida enla rata tras la administraci\u00f3n de una \u00fanica dosis de estreptozotocina (stz, 60 mg\/kg peso, i.P., En veh\u00edculo citrato a ph 4.00).  stz, determin\u00f3 incrementos muy significativos de la glucosa plasm\u00e1tica, del porcentaje de hemoglobina glucosilada (%ghb), fructosamina, triglic\u00e9ridos en ambos periodos de estudio del colesterol (12 semanas) y descenso del hdl-c. Sobre los par\u00e1metros indicativos de estr\u00e9s oxidativo, determin\u00f3 descenso del gsh eritrocitario y un incremento de malonaldehido (mda)indicativo del grado de lipoperoxidaci\u00f3n en los medios estudiados (plasma, cerebro e h\u00edgado) a las 6 y 12 semanas. Ambas dosis de mel ocasionaron descensos significativos de la glucosa plasm\u00e1tica (p&lt;0,001), fructosamina (p&lt;0,01), triglic\u00e9ridos (p&lt;0,001), colesterol total (p&lt;0,01) y aumento de hdl-c. respecto al %ghb solo descendi\u00f3 con la dosis de 100 ug a las 6 semanas. los valores de gsh se vieron incrementados junto a un descenso de los niveles de mda en todos los medios. Estos resultados muestran un potente efecto antioxidante de mel en la diabetes y estr\u00e9s oxidativo inducidos por stz.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Melatonina en la diabetes experimental y estr\u00e9s oxidativo inducidos en la rata por la administraci\u00f3n de estreptozotocina<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Melatonina en la diabetes experimental y estr\u00e9s oxidativo inducidos en la rata por la administraci\u00f3n de estreptozotocina <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Vargas Fresno <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/05\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro Montilla Lopez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Castillo rodriguez <\/li>\n<li>Rafael Del pozo  guzman (vocal)<\/li>\n<li>Juan  Miguel Gutierrez montalve (vocal)<\/li>\n<li>argimiro Rodriguez jerez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Vargas Fresno El presente trabajo muestra el efecto de dos dosis de melatonina (mel, 50 y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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