{"id":38243,"date":"1998-11-06T00:00:00","date_gmt":"1998-11-06T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/variabilidad-de-la-respuesta-linfocitaria-gamma-delta-a-la-estimulacion-in-vitro-con-cepa-micobacteriana-h37ra\/"},"modified":"1998-11-06T00:00:00","modified_gmt":"1998-11-06T00:00:00","slug":"variabilidad-de-la-respuesta-linfocitaria-gamma-delta-a-la-estimulacion-in-vitro-con-cepa-micobacteriana-h37ra","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/variabilidad-de-la-respuesta-linfocitaria-gamma-delta-a-la-estimulacion-in-vitro-con-cepa-micobacteriana-h37ra\/","title":{"rendered":"Variabilidad de la respuesta linfocitaria gamma\/delta a la estimulaci\u00f3n in vitro con cepa micobacteriana h37ra"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Diego M\u00e1rquez Medina <\/strong><\/h2>\n<p>Para evaluar el efecto in vitro de la estimulaci\u00f3n con la cepa micobacteriana h37ra sobre cultivos de pbmc, y en especial sobre sus linfocitos gama\/delta, extrajimos y asilamos c\u00e9lulas mononucleares de la sangre perif\u00e9rica de sujetos sanos y de enfermos con tuberculosis pulmonar activa vih y las cultivamos durante tres o siete d\u00edas a distintas concentraciones de h37ra y\/o il 2 ex\u00f3gena. Valorando pues las siguientes variables: concentraci\u00f3n de h37ra, de il 2, de ambos, tiempo de cultivo, aclaramiento del ant\u00edgeno a lo largo del cultivo y estado de salud del sujeto del que se estra\u00edan las muestras, encontrando que:  analizando por citometr\u00eda de flujo las muestras marcadas con anticuerpos monoclonales fluorescentes, la presencia de h37ra y la dosis de il 2 incrementan el porcentaje de linfocitos gd del cultivo con mayor intensidad en sujetos sanos que en enfermos tuberculosos pero que si nos centramos \u00fanicamente en los cd activos, la activaci\u00f3n en ambos grupos se realiza de manera similar, de manera que la diferente respuesta gama\/delta detallada en la bibliograf\u00eda dependiendo del estado de salud del sujeto s\u00f3lo es cierta respecto a los gamma\/delta totales, presentando el sujeto sano un fondo de reserva del que carece el enfermo tuberculoso, pero una similar activaci\u00f3n con les des.  para profundizar en el an\u00e1lisis de la respuesta gamma\/delta y tratar de averiguar por que exist\u00eda una carencia en el enfermo, estudiamos la apoptosis gamma\/delta es superior entre las c\u00e9lulas procedentes de enfermos tuberculosos y que aumenta con la presencia de mico-bacteria en el medio, siendo en este caso un factor protector la dosis anadisa de il 2 exogena.  la estimulaci\u00f3n continuada con el ant\u00edgeno induce mayor respuesta que su progresivo aclaramiento, igual que el cultivo de una semana de duraci\u00f3n supera el de tres d\u00edas en la proliferaci\u00f3n y activaci\u00f3n de linfocitos gamma\/delta.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Variabilidad de la respuesta linfocitaria gamma\/delta a la estimulaci\u00f3n in vitro con cepa micobacteriana h37ra<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Variabilidad de la respuesta linfocitaria gamma\/delta a la estimulaci\u00f3n in vitro con cepa micobacteriana h37ra <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Diego M\u00e1rquez Medina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 11\/06\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Pedro S\u00e1nchez Guijo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jose Pe\u00f1a Martinez <\/li>\n<li>Jos\u00e9 Pe\u00f1a amaro (vocal)<\/li>\n<li>Jos\u00e9 Luis Garc\u00eda  puche (vocal)<\/li>\n<li>jer\u00f3nimo Pachon d\u00edaz (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Diego M\u00e1rquez Medina Para evaluar el efecto in vitro de la estimulaci\u00f3n con la cepa micobacteriana h37ra [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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