{"id":38257,"date":"2018-03-09T09:37:45","date_gmt":"2018-03-09T09:37:45","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/els-mecanismes-moleculars-i-bioquimics-implicats-en-la-secrecio-regulada-del-pai-1\/"},"modified":"2018-03-09T09:37:45","modified_gmt":"2018-03-09T09:37:45","slug":"els-mecanismes-moleculars-i-bioquimics-implicats-en-la-secrecio-regulada-del-pai-1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/els-mecanismes-moleculars-i-bioquimics-implicats-en-la-secrecio-regulada-del-pai-1\/","title":{"rendered":"Els mecanismes moleculars i bioquimics implicats en la secrecio regulada del pai-1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Lourdes Gombau Suarez <\/strong><\/h2>\n<p>Informaci\u00f3n reciente sugiere que la deposici\u00f3n localizada de los inhibidores de proteasas es uno de los mecanismos que regulan la proteolisis pericelular durante la invasi\u00f3n del tejido, motivo por el cual se estudi\u00f3 la distribuci\u00f3n del inhibidor del activador del plasmin\u00f3geno de tipo 1 (pai-1) asociado con la l\u00ednea celular invasiva de glioma humano u-251.  el pai-1 antigeno fue detectado inmunol\u00f3gicamente en el interior de los gr\u00e1nulos citoplasm\u00e1ticos situados en los extremos de las prolongaciones citoplasm\u00e1ticas de las c\u00e9lulas u-251, siendo liberado r\u00e1pidamente en presencia de un est\u00edmulo. El an\u00e1lisis funcional del pai-1 almacenado en gr\u00e1nulos citoplasm\u00e1ticos situados en los extremos de las prolongaciones citoplasm\u00e1ticas de las c\u00e9lulas u-251, siendo liberado r\u00e1pidamente en presencia de un est\u00edmulo. El an\u00e1lisis funcional del pai-1 almacenado en gr\u00e1nulos revel\u00f3 la presencia de su conformaci\u00f3n activa.  los resultados arriba indicados sugieren que la capacidad del pai-1 para ser almacenado y liberado de forma r\u00e1pida puede proporcionar un mecanismo alternativo por el que estos tumores podr\u00edan regular la actividad proteol\u00edtica de forma localizada.  pai-1 se detect\u00f3 inicialmente en los gr\u00e1nulos    de las plaquetas, aunque pr\u00e1cticamente se desconoce su origen, es decir si es endocitado o bi\u00e9n sintetizado por los megacariocitos y posteriormente almacenado en gr\u00e1nulos.  para valorar la aplicabilidad de un sistema modelo celular que nos permita estudiar el mecanismo que determina el almacenamiento de pai-1 en plaquetas y en c\u00e9lulas de glioma humano (u-251), expresamos ex\u00f3genamente pai-1 humano en c\u00e9lulas att-20, una l\u00ednea celular de pituitaria de rat\u00f3n conocida por su capacidad de almacenar proteinas de forma regulada.  en este estudio se puso de manifiesto la capacidad de las c\u00e9lulas att-20 de almacenar pai-1 en gr\u00e1nulos de secreci\u00f3n y de liberarlo en funci\u00f3n de un est\u00edmulo.  tambi\u00e9n se de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Els mecanismes moleculars i bioquimics implicats en la secrecio regulada del pai-1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Els mecanismes moleculars i bioquimics implicats en la secrecio regulada del pai-1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Lourdes Gombau Suarez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/06\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jer\u00f3nimo Blanco Fern\u00e1ndez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: merce Durfort coll <\/li>\n<li>dolors Ludevid m\u00fagica (vocal)<\/li>\n<li>Antonio Zorzano olarte (vocal)<\/li>\n<li>roser L\u00f3pez alemany (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lourdes Gombau Suarez Informaci\u00f3n reciente sugiere que la deposici\u00f3n localizada de los inhibidores de proteasas es uno [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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