{"id":38310,"date":"2018-03-09T09:37:49","date_gmt":"2018-03-09T09:37:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/bases-moleculares-de-la-biogenesis-mitocondrial-analisis-del-promotor-del-gen-humano-de-la-subunidad-beta-f1-atp-sintetasa\/"},"modified":"2018-03-09T09:37:49","modified_gmt":"2018-03-09T09:37:49","slug":"bases-moleculares-de-la-biogenesis-mitocondrial-analisis-del-promotor-del-gen-humano-de-la-subunidad-beta-f1-atp-sintetasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/bases-moleculares-de-la-biogenesis-mitocondrial-analisis-del-promotor-del-gen-humano-de-la-subunidad-beta-f1-atp-sintetasa\/","title":{"rendered":"Bases moleculares de la biogenesis mitocondrial: analisis del promotor del gen humano de la subunidad beta-f1-atp sintetasa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josep Antoni Villena Delgado <\/strong><\/h2>\n<p>Se han caracterizado los principales elementos responsables de la regulaci\u00f3n transcripcional del gen beta-f1-atp sintetasa en diversas l\u00edneas de c\u00e9lulas transformadas en activa proliferaci\u00f3n y durante el proceso de diferenciaci\u00f3n del adipocito marr\u00f3n.  en ambos modelos, la principal regi\u00f3n responsable de la actividad del promotor de dicho gen es la comprendida entre los nucle\u00f3tidos -306\/-266, si bien los factores cis- y trans-reguladores implicados son diferentes en uno y otro modelo. Asi, la transcripci\u00f3n del gen en c\u00e9lulas transformadas depende mayoritariamente de una caja gc at\u00edpica (-294\/-289) a la que se unen los factores sp1, principalmente, y sp3. En cambio, durante el proceso de diferenciaci\u00f3n del adipocito marr\u00f3n, en el cual se produce una fuerte inducci\u00f3n de los niveles de mrna b-f1-atp sintetasa- y otros genes oxphos-, el gen es regulado por el factor nrf-2\/gabp perteneciente a la familia ets de factores de transcripci\u00f3n, cuya expresi\u00f3n se induce de forma importante durante el inicio del proceso de diferenciaci\u00f3n celular del adipocito marr\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Bases moleculares de la biogenesis mitocondrial: analisis del promotor del gen humano de la subunidad beta-f1-atp sintetasa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Bases moleculares de la biogenesis mitocondrial: analisis del promotor del gen humano de la subunidad beta-f1-atp sintetasa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josep Antoni Villena Delgado <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/06\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francesc Villarroya Gombau<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zorzano olarte <\/li>\n<li>virginia Nunes mart\u00ednez (vocal)<\/li>\n<li>jordi Casademont pou (vocal)<\/li>\n<li>Mar\u00eda  Luisa Bonet pi\u00f1a (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josep Antoni Villena Delgado Se han caracterizado los principales elementos responsables de la regulaci\u00f3n transcripcional del gen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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