{"id":38336,"date":"2018-03-09T09:37:51","date_gmt":"2018-03-09T09:37:51","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/comparacion-del-indice-t-p-valle-pico-entre-lisinopril-y-captopril-en-pacientes-hipertensos\/"},"modified":"2018-03-09T09:37:51","modified_gmt":"2018-03-09T09:37:51","slug":"comparacion-del-indice-t-p-valle-pico-entre-lisinopril-y-captopril-en-pacientes-hipertensos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/comparacion-del-indice-t-p-valle-pico-entre-lisinopril-y-captopril-en-pacientes-hipertensos\/","title":{"rendered":"Comparacion del indice t\/p (valle\/pico) entre lisinopril y captopril en pacientes hipertensos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Pardo Oller <\/strong><\/h2>\n<p>Introduccion. La importancia de las pautas de administraci\u00f3n de los f\u00e1rmacos antihipertensivos deriva de las marcadas fluctuaciones de la pa a lo largo de las 24h del dia por ello la monitorizacion ambulatoria de la pa (mapa), que consiste en un registro continuo de la pa por un m\u00e9todo oscilometrico, se consigue observar el ritmo circadiano de la pa, presentando un ciclo vigilia\/sue\u00f1o, que seg\u00fan esto distinguimos:  dippers: sujetos que presentan un descenso fisiol\u00f3gico de la pa mayor del 10%.  no dippers: sujetos que el descenso es inferior al 10%.  entre las aplicaciones del mapa, tenemos confirmar el diagnostico de hta en casos dudosos, detectar hipertensos de bata blanca, que son aquellos que presenta una reacci\u00f3n de alarma con elevaci\u00f3n de la pa ante su medici\u00f3n por personal sanitario en un ambiente sanitario.  la fda ha propuesto el indice t\/p para evaluar la duraci\u00f3n y la magnitud de la reducci\u00f3n de la pa de un f\u00e1rmaco antihipertensivo. Siendo t el efecto residual hipotensor justo antes de la toma siguiente del f\u00e1rmaco, y p el descenso maximo% de la pa con dicho f\u00e1rmaco, sustrayendo el efecto placebo. El cociente entre t\/p nos dar\u00e1 un indice que oscila de 0 a 1, considerando la fda que un f\u00e1rmaco es valido para controlar la pa si es mayor de 0,5. Se considera que un paciente es respondedor a un f\u00e1rmaco antihipertensivo por mapa si con el se consigue un descenso de pas de 10 mmhg o\/y de pad de 5 mmhg.  pacientes y metodos. Partimos de 95 pacientes hipertensos leves o moderados que cumplen unos criterios de inclusi\u00f3n, en los que se pone un tto con placebo de 2 semanas de duraci\u00f3n, tras lo cual se realiza el primer mapa, obteniendo 54 pacientes considerados hipertensos (pad media diurna mayor 85mmhg), 37 hipertensos de bata blanca y 4 no v\u00e1lidos. Distribuimos aleatoriamente esos 54 pacientes en dos grupos de tratamiento, 28 en tto con lisinopril y 26 con captopril: tras llevar 4 semanas en tratamiento c<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Comparacion del indice t\/p (valle\/pico) entre lisinopril y captopril en pacientes hipertensos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Comparacion del indice t\/p (valle\/pico) entre lisinopril y captopril en pacientes hipertensos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Pardo Oller <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 26\/06\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Blas Gil Extremera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: jos\u00e9 Raya mu\u00f1oz <\/li>\n<li>Jos\u00e9 ram\u00f3n Vicente rull (vocal)<\/li>\n<li>Fernando Yelamos rodriguez (vocal)<\/li>\n<li>  (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Pardo Oller Introduccion. La importancia de las pautas de administraci\u00f3n de los f\u00e1rmacos antihipertensivos deriva de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,156],"tags":[3355,57027,35528,39200,99660],"class_list":["post-38336","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-patologia","tag-blas-gil-extremera","tag-fernando-yelamos-rodriguez","tag-jose-ramon-vicente-rull","tag-jose-raya-munoz","tag-rafael-pardo-oller"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38336","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38336"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38336\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38336"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38336"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38336"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}