{"id":38455,"date":"2018-03-09T09:38:02","date_gmt":"2018-03-09T09:38:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-factor-transformante-del-crecimiento-b1-en-la-fibrosis-hepatica-estudio-clinico-y-experimental\/"},"modified":"2018-03-09T09:38:02","modified_gmt":"2018-03-09T09:38:02","slug":"influencia-del-factor-transformante-del-crecimiento-b1-en-la-fibrosis-hepatica-estudio-clinico-y-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-factor-transformante-del-crecimiento-b1-en-la-fibrosis-hepatica-estudio-clinico-y-experimental\/","title":{"rendered":"Influencia del factor transformante del crecimiento b1 en la fibrosis hepatica.  estudio clinico y experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marta Gasso Chumillas <\/strong><\/h2>\n<p>El factor transformante del crecimiento beta1 (tgfbeta1) es la citoquina que m\u00e1s se ha asociado con los procesos de fibrosis. En esta tesis se pretende conocer la influencia del tgfbeta1 en los procesos implicados en la fibrosis hep\u00e1tica, tanto por lo que respecta a la sintesis como a la degradaci\u00f3n de los componentes de la matriz extracelular, a nivel experimental y cl\u00ednico. Para ello se establecieron los siguientes objetivos: 1.  estudiar si el efecto del acetaldehido sobre la sintesis de col\u00e1geno puede ser debido a un aumento del tgfbeta1;2.  estudiar los efectos de la administraci\u00f3n de same sobre la lipoperoxidaci\u00f3n lip\u00eddica, la fibrog\u00e9nesis hep\u00e1tica y la expresi\u00f3n del tgfbeta1 en un modelo experimental de cirrosis por cci4 una vez iniciado el da\u00f1o hep\u00e1tico, 3.  evaluar la utilidad de los marcadores actuales de fibrosis y fibrog\u00e9nesis y estudiar el papel del tgfbeta en el desarrollo de la fibrosis hep\u00e1tica en enfermos hepat\u00f3patas cr\u00f3nicos. Las conclusiones principales de esta tesis fueron:1. En la fibrosis hep\u00e1tica experimental hay un aumento en la expresi\u00f3n del col\u00e1geno, del tgfbeta1 y de la mmp2. Este estudio muestra que esto se correlaciona con la lipoperoxidaci\u00f3n y que el same atenua los efectos provocados por el cci4;2. El acetaldehido puede inducir lipoperoxidaci\u00f3n en c\u00e9lulas hepg2 y en c\u00e9lulas estrelladas y que este efecto se acompa\u00f1a de un incremento en la expresi\u00f3n y sintesis del tgfbeta1, indicando que el efecto del acetaldehido sobre la fibrosis hep\u00e1tica peude ser mediado por el tgfbeta1;3.  los marcadores de fibrosis y fibrog\u00e9nesis actuales se correlacionan con los niveles de expresi\u00f3n del col\u00e1geno en el higado de los enfermos hepat\u00f3patras cr\u00f3nicos, confirmando su utilidad.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del factor transformante del crecimiento b1 en la fibrosis hepatica.  estudio clinico y experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del factor transformante del crecimiento b1 en la fibrosis hepatica.  estudio clinico y experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marta Gasso Chumillas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 16\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Albert Par\u00e9s Darnaculleta<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: oriol Bachs valldeneu <\/li>\n<li>Santiago Nogue xarau (vocal)<\/li>\n<li>Jorge Camps andreu (vocal)<\/li>\n<li>xavier Par\u00e9s casasampera (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marta Gasso Chumillas El factor transformante del crecimiento beta1 (tgfbeta1) es la citoquina que m\u00e1s se ha [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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