{"id":38466,"date":"2018-03-09T09:38:02","date_gmt":"2018-03-09T09:38:02","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/repercusion-del-tratamiento-antiepileptico-prolongado-sobre-la-funcion-tiroidea-y-el-metabolismo-lipidico\/"},"modified":"2018-03-09T09:38:02","modified_gmt":"2018-03-09T09:38:02","slug":"repercusion-del-tratamiento-antiepileptico-prolongado-sobre-la-funcion-tiroidea-y-el-metabolismo-lipidico","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/repercusion-del-tratamiento-antiepileptico-prolongado-sobre-la-funcion-tiroidea-y-el-metabolismo-lipidico\/","title":{"rendered":"Repercusion del tratamiento antiepileptico prolongado sobre la funcion tiroidea y el metabolismo lipidico."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jes\u00fas Manuel Eiris Pu\u00f1al <\/strong><\/h2>\n<p>Introduccion: la epilepsia es un trastorno cr\u00f3nico que obliga en muchas ocasiones a la instauraci\u00f3n y posterior mantenimiento de un tratamiento antiepil\u00e9ptico prolongado. A lo largo de los \u00faltimos a\u00f1os se han referido modificaciones en los par\u00e1metros de funci\u00f3n tiroidea y del perfil lip\u00eddico en relaci\u00f3n con la administraci\u00f3n de algunos f\u00e1rmacos antiepil\u00e9pticos (faes). Si bien los resultados no son homog\u00e9neos, se han referido descensos de las hormonas tiroideas para carbamacepina (cbz) y difenilhidanto\u00edna (dph), no variaciones para el \u00e1cido valproico (avp) y hallazgos variables para el fb. En relaci\u00f3n al perfil lip\u00eddico los hallazgos descritos acerca de la repercusi\u00f3n sobre el colesterol total (ct), o sus fracciones (hdl, ldl y vldl) as\u00ed como sobre la eventual modificaci\u00f3n del riesgo aterog\u00e9nico, tampoco son superponibles en los diferentes estudios.  objetivo: valorar si la administraci\u00f3n de 3 faes de amplia utilizaci\u00f3n pedi\u00e1trica -cbz, avp y fb- inducen cambios en el perfil lip\u00eddico y\/o tiroideo y la hipot\u00e9tica relaci\u00f3n de las modificaciones con factores como la dosis o nivel del f\u00e1rmaco y la edad o sexo de los pacientes.  material y metodos: estudio comparativo de distintas variables de perfil tiroideo (t3, t4, ft4, tbg y tsh) y de perfil lip\u00eddico (ct, hdl, ldl, vldl y triglic\u00e9ridos) en 289 ni\u00f1os de edad comprendida entre 5-15 a\u00f1os, de los cuales 148 son controles sanos y 141 epil\u00e9pticos bajo tratamiento cr\u00f3nico superior a 1 a\u00f1o con cbz (51 casos), avp (51 casos) y fb (29 casos).  resultados: grupo de cbz: disminuci\u00f3n de t3, t4, ft4, tbg y aumento de tsh; aumento de ct, hdl y ldl. Grupo de avp:  disminuci\u00f3n de t3, t4, ft4, tbg y aumento de tsh; descenso de ct y ldl. Grupo de fb: disminuci\u00f3n de t4 y ft4. Aumento de ldl en los varones.  conclusiones: los faes estudiados modifican el perfil tiroideo y lip\u00eddico en la edad pedi\u00e1trica induciendo una disminuci\u00f3n de los valores de hormonas t<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Repercusion del tratamiento antiepileptico prolongado sobre la funcion tiroidea y el metabolismo lipidico.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Repercusion del tratamiento antiepileptico prolongado sobre la funcion tiroidea y el metabolismo lipidico. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jes\u00fas Manuel Eiris Pu\u00f1al <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Castro Gago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Tojo sierra <\/li>\n<li>Santiago Rodr\u00edguez-segade villamar\u00edn (vocal)<\/li>\n<li>Rafael Palencia luaces (vocal)<\/li>\n<li>Emilio Fernandez alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jes\u00fas Manuel Eiris Pu\u00f1al Introduccion: la epilepsia es un trastorno cr\u00f3nico que obliga en muchas ocasiones a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,139,1880,977],"tags":[767,99880,35008,12810,2517,671],"class_list":["post-38466","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-medicina-interna","category-neurologia","category-santiago-de-compostela","tag-emilio-fernandez-alvarez","tag-jesus-manuel-eiris-punal","tag-manuel-castro-gago","tag-rafael-palencia-luaces","tag-rafael-tojo-sierra","tag-santiago-rodriguez-segade-villamarin"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38466","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38466"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38466\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38466"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38466"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38466"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}