{"id":38471,"date":"2018-03-09T09:38:03","date_gmt":"2018-03-09T09:38:03","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cancer-de-mama-y-micronutrientes-antioxidantes-un-estudio-transversal-en-lacurva-dosis-tiempo\/"},"modified":"2018-03-09T09:38:03","modified_gmt":"2018-03-09T09:38:03","slug":"cancer-de-mama-y-micronutrientes-antioxidantes-un-estudio-transversal-en-lacurva-dosis-tiempo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cancer-de-mama-y-micronutrientes-antioxidantes-un-estudio-transversal-en-lacurva-dosis-tiempo\/","title":{"rendered":"Cancer de mama y micronutrientes antioxidantes: un estudio transversal en lacurva dosis\/tiempo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda Sande Meijide <\/strong><\/h2>\n<p>Introduccion: la literatura confirma de modo experimental el papel de defensa frente al da\u00f1o oxidativo causado por los radicales libres con potencial mut\u00e1genico del b-caroteno, vitamina e y vitamina c, actuando la vitamina a en una etapa posterior, controlando la proliferaci\u00f3n de la c\u00e9lula neopl\u00e1sica reci\u00e9n generada.  objetivo general: analizar y comparar las diferencias en las curvas de niveles plasm\u00e1ticos (curvas dosis\/tiempo) despu\u00e9s de la administraci\u00f3n oral de una \u00fanica dosis de vitaminas antioxidantes a un grupo de enfermas con c\u00e1ncer de mama y a un grupo control.  sujetos y metodos: estudio epidemiol\u00f3gico de corte o transversal que incorpora una intervenci\u00f3n (administraci\u00f3n de una \u00fanica dosis oral de: 45mg de beta-caroteno, 225 mg de acetato de alfa-tocoferol y 450 mg de \u00e1cido asc\u00f3rbico) para comparar la curva dosis\/tiempo en dos grupos: pacientes con diagn\u00f3stico de c\u00e1ncer de mama y extensi\u00f3n local o regional de neoplasia (casos) y pacientes que nunca fueron diagnosticadas de c\u00e1ncer (controles).  se determinaron en plasma simult\u00e1neamente el retinol, beta-caroteno, y alfa-tocoferol por medio de la t\u00e9cnica de cromatograf\u00eda l\u00edquida de alta eficacia. El \u00e1cido asc\u00f3rbico se midi\u00f3 con una t\u00e9cnica fluorim\u00e9trica. Los tiempos de medici\u00f3n fueron: en el momento basal previo a la ingesta, y a las 2, a las 6, a las 8, a las 24 y a las 48 horas de la misma. Fueron creadas una serie de variables referentes a la respuesta plasm\u00e1tica: \u00e1rea bajo la curva dosis\/tiempo y m\u00e1ximos cambios absolutos y relativos desde el nivel basal. El an\u00e1lisis estad\u00edstico de los datos se basa en el an\u00e1lisis de la covariancia, utilizando esta t\u00e9cnica para la comparaci\u00f3n de las variables referentes a la respuesta plasm\u00e1tica y utilizando el an\u00e1lisis de la covariancia de medidas repetidas para la comparaci\u00f3n de la curva de niveles plasm\u00e1ticos considerada de modo global.  resultados: la curva de niveles plasm\u00e1ticos para<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cancer de mama y micronutrientes antioxidantes: un estudio transversal en lacurva dosis\/tiempo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cancer de mama y micronutrientes antioxidantes: un estudio transversal en lacurva dosis\/tiempo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda Sande Meijide <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 17\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Miguel Barros Dios<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Jes\u00fas Gestal otero <\/li>\n<li>ram\u00f3n Soto otero (vocal)<\/li>\n<li>lLuis Serra majem (vocal)<\/li>\n<li>Manuel Dominguez  carmona (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda Sande Meijide Introduccion: la literatura confirma de modo experimental el papel de defensa frente al da\u00f1o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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