{"id":38503,"date":"2018-03-09T09:38:06","date_gmt":"2018-03-09T09:38:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/monitorizacion-del-transcrito-pml-rar-alfa-mediante-la-reaccion-en-cadena-de-la-polimerasa-en-la-leucemia-aguda-promieloca%c2%adtica-tras-trasplante-de-medula-osea\/"},"modified":"2018-03-09T09:38:06","modified_gmt":"2018-03-09T09:38:06","slug":"monitorizacion-del-transcrito-pml-rar-alfa-mediante-la-reaccion-en-cadena-de-la-polimerasa-en-la-leucemia-aguda-promieloca%c2%adtica-tras-trasplante-de-medula-osea","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/monitorizacion-del-transcrito-pml-rar-alfa-mediante-la-reaccion-en-cadena-de-la-polimerasa-en-la-leucemia-aguda-promieloca%c2%adtica-tras-trasplante-de-medula-osea\/","title":{"rendered":"Monitorizaci\u00f3n del transcrito pml\/rar alfa mediante la reacci\u00f3n en cadena de la polimerasa en la leucemia aguda promieloc\u00edtica tras trasplante de m\u00e9dula \u00f3sea."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carmen Martin Calvo <\/strong><\/h2>\n<p>La leucemia aguda promieloc\u00edtica es un subtipo de leucemia aguda mielobl\u00e1stica caracterizada por la presencia del gen de fusi\u00f3n pml\/rar alfa resultante de la translocaci\u00f3n t(15;17). Numerosos autores han demostrado que el estudio de la enfermedad m\u00ednima residual en esta leucemia mediante la reacci\u00f3n en cadena de la polimerasa (pcr) para el arnm de fusi\u00f3n pml\/rar alfa es muy eficaz en el manejo cl\u00ednico de la enfermedad, ya que es \u00fatil para predecir la reca\u00edda e identificar a aquellos pacientes que necesitan m\u00e1s terapia antileuc\u00e9mica. Sin embargo no hay grandes series publicadas que estudien la enfermedad m\u00ednima residual y su significaci\u00f3n en largos supervivientes tras trasplante de m\u00e9dula \u00f3sea.  he estudiado mediante rt-pcr para el transcrito pml\/rar alfa a 22 pacientes sometidos a trasplante aut\u00f3logo de progenitores hematopoy\u00e9ticos (10 pacientes) o trasplante alog\u00e9nico de m\u00e9dula \u00f3sea (12 pacientes), usando dos protocolos de rt-pcr diferentes (borrow et al. Br j haematol 1992; 82: 529, y biondi et al. Blood 1992; 80: 492). Se han analizado un total de 78 muestras de m\u00e9dula \u00f3sea post-trasplante obtenidas entre 1 al 168 meses post-trasplante. en 6 de los trasplantes aut\u00f3logos se estudi\u00f3 adem\u00e1s la presencia del transcrito pml\/rar alfa en los progenitores infundidos y 8 pacientes (4 alog\u00e9nicos y 4 aut\u00f3logos) fueron estudiados para la presencia de dicho transcrito justo antes del transplante. De estos 8 pacientes, 5 fueron positivos para la presencia del transcrito; 3 de ellos se negativizaron precozmente post-trasplante y se han mantenido negativos a lo largo de la evoluci\u00f3n post-trasplante, pero los otros 2 se mantuvieron positivos y recayeron. Se produjeron otras 2 reca\u00eddas post-trasplante; una de ellas fue precedida por una positivizaci\u00f3n del transcrito pml\/rar alta 2 meses antes. En la otra reca\u00edda, una muestra obtenida 4,5 meses antes de la reca\u00edda fue negativa. El resto de las muestras post-trasplante anal<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Monitorizaci\u00f3n del transcrito pml\/rar alfa mediante la reacci\u00f3n en cadena de la polimerasa en la leucemia aguda promieloc\u00edtica tras trasplante de m\u00e9dula \u00f3sea.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Monitorizaci\u00f3n del transcrito pml\/rar alfa mediante la reacci\u00f3n en cadena de la polimerasa en la leucemia aguda promieloc\u00edtica tras trasplante de m\u00e9dula \u00f3sea. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carmen Martin Calvo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 23\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Santamaria ossorio <\/li>\n<li>pascual Bolufer gilabert (vocal)<\/li>\n<li>Rafael Ram\u00edrez cahmond (vocal)<\/li>\n<li>montserrat Baiget bast\u00fas (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carmen Martin Calvo La leucemia aguda promieloc\u00edtica es un subtipo de leucemia aguda mielobl\u00e1stica caracterizada por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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