{"id":38513,"date":"2018-03-09T09:38:06","date_gmt":"2018-03-09T09:38:06","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/implicaciones-del-factor-tisular-en-la-patogenesis-del-sa%c2%adndrome-antifosfola%c2%adpido\/"},"modified":"2018-03-09T09:38:06","modified_gmt":"2018-03-09T09:38:06","slug":"implicaciones-del-factor-tisular-en-la-patogenesis-del-sa%c2%adndrome-antifosfola%c2%adpido","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/implicaciones-del-factor-tisular-en-la-patogenesis-del-sa%c2%adndrome-antifosfola%c2%adpido\/","title":{"rendered":"Implicaciones del factor tisular en la patog\u00e9nesis del s\u00edndrome antifosfol\u00edpido"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana M. Jurado Porcel <\/strong><\/h2>\n<p>El s\u00edndrome antifosfol\u00edpido es un estado de hipercoagulabilidad que se caracteriza por la presencia de trombosis arteriales y\/o venosas, p\u00e9rdidas fetales recurrentes y\/o trombocitopenia. Las trombosis pueden ocurrir en cualquier localizaci\u00f3n del \u00e1rbol vascular y, a diferencia de otras coagulopat\u00edas, pueden ser tanto arteriales como venosas. Adem\u00e1s de estas caracter\u00edsticas cl\u00ednicas es t\u00edpica la presencia de anticuerpos antifosfol\u00edpido, principalmente anticuerpos anticardiolipin y anticoagulantes l\u00fapico.  a principios de esta d\u00e9cada se vi\u00f3 que los anticuerpos antifosfol\u00edpido no ve un\u00edan a los fosfol\u00edpidos a menos que estuviera presenta una prote\u00edna plasm\u00e1tica, identificada como la beta2-glicoprote\u00edna i, la cual sufrir\u00eda un cambio en su conformaci\u00f3n dando lugar a la aparici\u00f3n de un ep\u00edtope antig\u00e9nico.  se han implicado varios mecanismos en la patogenia de las trombosis que ocurren en este s\u00edndrome, tales como plaquetas, las c\u00e9lulas endoteliales, los sistemas reguladores de la coagulaci\u00f3n, la beta2-glicoprote\u00edna i y el factor tisular, que es el mayor iniciador de la coagulaci\u00f3n in vivo.  en nuestro estudio, intentamos relacionar la posible asociaci\u00f3n de los fen\u00f3menos tromb\u00f3ticos que presentan estos pacientes, con el grado de expresi\u00f3n del factor tisular, para lo cual se realizaron diversos abordajes funcionales e inmunol\u00f3gicos, tales como medici\u00f3n de la expresi\u00f3n del factor tisular en la superficie celular, determinaci\u00f3n del contenido antig\u00e9nico (tf ag) en lisados celulares, valoraci\u00f3n de la capacidad funcional mediante el estudio de la actividad procoagulante, tanto en c\u00e9lulas intactas como en lisadas, cuantificaci\u00f3n del factor tisular soluble en plasma y an\u00e1lisis de la expresi\u00f3n del arnm-tf mediante retrotranscripci\u00f3n y reacci\u00f3n en cadena de la polimerasa. Nuestros resultados muestran que en los pacientes con s\u00edndrome antifosfol\u00edpido primario y trombosis existe un incremento en los niveles de<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Implicaciones del factor tisular en la patog\u00e9nesis del s\u00edndrome antifosfol\u00edpido<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Implicaciones del factor tisular en la patog\u00e9nesis del s\u00edndrome antifosfol\u00edpido <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana M. Jurado Porcel <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 24\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M.jose Cuadrado Lozano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro S\u00e1nchez guijo <\/li>\n<li>jordi Fontcuberta boj (vocal)<\/li>\n<li>Antonio L\u00f3pez beltr\u00e1n (vocal)<\/li>\n<li>Francisco j. Tinahones madue\u00f1o (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana M. Jurado Porcel El s\u00edndrome antifosfol\u00edpido es un estado de hipercoagulabilidad que se caracteriza por la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,973,218,139,877],"tags":[99965,7892,75340,14244,20825,1935],"class_list":["post-38513","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cordoba","category-hematologia","category-medicina-interna","category-reumatologia","tag-ana-m-jurado-porcel","tag-antonio-lopez-beltran","tag-francisco-j-tinahones-madueno","tag-jordi-fontcuberta-boj","tag-m-jose-cuadrado-lozano","tag-pedro-sanchez-guijo"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38513","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38513"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38513\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38513"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38513"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38513"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}