{"id":38542,"date":"2018-03-09T09:38:09","date_gmt":"2018-03-09T09:38:09","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/caracterizacion-y-preparacion-de-estandares-de-toxinas-psp-e-iniciacion-al-estudio-de-su-aislamiento-via-reconocimiento-molecular\/"},"modified":"2018-03-09T09:38:09","modified_gmt":"2018-03-09T09:38:09","slug":"caracterizacion-y-preparacion-de-estandares-de-toxinas-psp-e-iniciacion-al-estudio-de-su-aislamiento-via-reconocimiento-molecular","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/caracterizacion-y-preparacion-de-estandares-de-toxinas-psp-e-iniciacion-al-estudio-de-su-aislamiento-via-reconocimiento-molecular\/","title":{"rendered":"Caracterizacion y preparacion de estandares de toxinas psp e iniciacion al estudio de su aislamiento via reconocimiento molecular."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ana Isabel Mesego Pazos <\/strong><\/h2>\n<p>Esta memoria se divide en dos partes. En la primera parte (parte a) se presenta el aislamiento, purificaci\u00f3n y cuantificaci\u00f3n de saxitoxina (stx) y la s\u00edntesis parcial de gonyautoxina v (gtx v). En la segunda parte (parte b) se describen los primeros estudios encaminados a la obtenci\u00f3n de un receptor lip\u00f3filo que reconozca y atrape en su interior a la stx.  parte a:  (1) identificaci\u00f3n y determinaci\u00f3n de toxinas psp por hplc (cap\u00edtulo 1).  (2) puesta a punto de una s\u00edntesis parcial de gtx-v a partir de stx (cap\u00edtulo 2). La gtx-v se identific\u00f3 por espectroscop\u00eda (1h-rmn, 13c-rmn y mhqc).  (3) desarrollo de un m\u00e9todo de separaci\u00f3n y purificaci\u00f3n de stx y dcstx por hplc a partir de una mezcla de ambas toxinas (cap\u00edtulo 3). La detecci\u00f3n de estas toxinas se realiz\u00f3 post-columna con un detector uv con el objeto de no destruir las toxinas. Como fase m\u00f3vil se utiliz\u00f3 tfa 0.1%. De esta forma se consigui\u00f3 separar con facilidad stx y dcstx. La stx dio un microan\u00e1lisis correcto.  (4) la muestra de dihidrocloruro de saxitoxina nstx-2hci) pura se oxid\u00f3 a purina por el m\u00e9todo de bates y rapoport obteni\u00e9ndose un \u00edndice de conversi\u00f3n de stx a purina (cap\u00edtulo 4). La cantidad de stx-2hci necesaria para obtener una disoluci\u00f3n de purina de absorbancia 1 result\u00f3 ser de 114.4 mg\/ml.  parte b:  se dise\u00f1\u00f3 con ayuda de estereomodelos cpk un receptor con la idea de que se una selectivamente a la stx-2hci y permita su extracci\u00f3n de la fase acuosa mediante disolventes org\u00e1nicos.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Caracterizacion y preparacion de estandares de toxinas psp e iniciacion al estudio de su aislamiento via reconocimiento molecular.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Caracterizacion y preparacion de estandares de toxinas psp e iniciacion al estudio de su aislamiento via reconocimiento molecular. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ana Isabel Mesego Pazos <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 31\/07\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Mouri\u00f1o Mosquera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Mar\u00eda no Franco  soler <\/li>\n<li>julio cesar Podesta lopez (vocal)<\/li>\n<li>ram\u00f3n Estevez cabanas (vocal)<\/li>\n<li>Jos\u00e9 Darias jerez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ana Isabel Mesego Pazos Esta memoria se divide en dos partes. En la primera parte (parte a) [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[17,416,977],"tags":[100009,9213,9944,21491,100010,21193],"class_list":["post-38542","post","type-post","status-publish","format-standard","hentry","category-quimica","category-quimica-organica","category-santiago-de-compostela","tag-ana-isabel-mesego-pazos","tag-antonio-mourino-mosquera","tag-jose-darias-jerez","tag-jose-maria-no-franco-soler","tag-julio-cesar-podesta-lopez","tag-ramon-estevez-cabanas"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38542","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38542"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38542\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38542"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38542"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38542"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}