{"id":38555,"date":"1998-09-09T00:00:00","date_gmt":"1998-09-09T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-diferencial-de-las-isoformas-de-la-sintasa-del-oxido-nitrico-en-la-cirrosis-hepatica-consecuencias-fisiopatologicas\/"},"modified":"1998-09-09T00:00:00","modified_gmt":"1998-09-09T00:00:00","slug":"expresion-diferencial-de-las-isoformas-de-la-sintasa-del-oxido-nitrico-en-la-cirrosis-hepatica-consecuencias-fisiopatologicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/expresion-diferencial-de-las-isoformas-de-la-sintasa-del-oxido-nitrico-en-la-cirrosis-hepatica-consecuencias-fisiopatologicas\/","title":{"rendered":"Expresion diferencial de las isoformas de la sintasa del oxido nitrico en la cirrosis hepatica: consecuencias fisiopatologicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Manuel Morales Ruiz <\/strong><\/h2>\n<p>El prop\u00f3sito del siguiente estudio es el de investigar si un incremento en la expresi\u00f3n de las isoformas de la sintasa del \u00f3xido n\u00edtrico tipo 2 y 3 (nos2 y nos3), estar\u00eda implicado en el fen\u00f3meno fisiopatol\u00f3gico de la vasodilataci\u00f3n arterial de la cirr\u00f3sis hep\u00e1tica. Debido a que los pacientes y las ratas cirr\u00f3ticas con ascitis est\u00e1n predispuestos a desarrollar peritonitis bacteriana espont\u00e1nea (pbe) en este estudio tambi\u00e9n se investig\u00f3 si los macr\u00f3fagos peritoneales de ratas y pacientes cirr\u00f3ticos expresan la nos2. El primer protocolo se realiz\u00f3 en aorta tor\u00e1cica, aorta abdominal y arteria mesent\u00e9rica de ratas controles y ratas cirr\u00f3ticas con ascitis. El arnm de nos2 se detect\u00f3 en las arterias de los animales cirr\u00f3ticos. Adem\u00e1s, se demostr\u00f3 la presencia de un aumento en la abundancia del arnm y de la prote\u00edna de nos3. En el segundo protocolo se determin\u00f3 la liberaci\u00f3n de no2 mediada por los cultivos primarios de macr\u00f3fagos de las ratas controles y las ratas cirr\u00f3ticas con ascitis y la expresi\u00f3n del arnm y de la prote\u00edna de nos2. Los macr\u00f3fagos de las ratas cirr\u00f3ticas producen no2 y los an\u00e1lisis de northern blot, western blot e inmunocitoqu\u00edmica mostraron la presencia del arnm y la prote\u00edna de nos2. Adem\u00e1s, la administraci\u00f3n de l-nil (un inhibidor de la actividad enzim\u00e1tica de nos2) provoc\u00f3 infecci\u00f3n peritoneal en las ratas cirr\u00f3ticas con ascitis.  en el tercer protocolo se analiz\u00f3 la producci\u00f3n de no en macr\u00f3fagos peritoneales de pacientes cirr\u00f3ticos con ascitis y pacientes cirr\u00f3ticos con pbe y pbe resuelta.  los pacientes cirr\u00f3ticos afectos de pbe presentaron una mayor concentraci\u00f3n de nox que los pacientes sin peritonitis, obteni\u00e9ndose las concentraciones m\u00e1s altas en el grupo de pacientes con pbe resuelta. Los macr\u00f3fagos de los pacientes con pbe y pbe resuelta producen no2 y expresaron el arnm y la prote\u00edna de nos2. En conclusi\u00f3n, estos resultados indican 1) la existencia d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresion diferencial de las isoformas de la sintasa del oxido nitrico en la cirrosis hepatica: consecuencias fisiopatologicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresion diferencial de las isoformas de la sintasa del oxido nitrico en la cirrosis hepatica: consecuencias fisiopatologicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Manuel Morales Ruiz <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 09\/09\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Wladimiro Jim\u00e9nez Povedano<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Santiago Lamas pel\u00e1ez <\/li>\n<li>pablo Engel rocamora (vocal)<\/li>\n<li>joan Claria enrich (vocal)<\/li>\n<li>josep Mar\u00eda Pique badia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Manuel Morales Ruiz El prop\u00f3sito del siguiente estudio es el de investigar si un incremento en la 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