{"id":38587,"date":"2018-03-09T09:38:13","date_gmt":"2018-03-09T09:38:13","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/expresion-diferencial-de-moleculas-de-adhesion-galectina-3-y-galectina-1-receptor-de-laminina-de-lata-afinidad-en-la-progresion-de-tumores-humanos\/"},"modified":"2018-03-09T09:38:13","modified_gmt":"2018-03-09T09:38:13","slug":"expresion-diferencial-de-moleculas-de-adhesion-galectina-3-y-galectina-1-receptor-de-laminina-de-lata-afinidad-en-la-progresion-de-tumores-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/expresion-diferencial-de-moleculas-de-adhesion-galectina-3-y-galectina-1-receptor-de-laminina-de-lata-afinidad-en-la-progresion-de-tumores-humanos\/","title":{"rendered":"Expresi\u00f3n diferencial de mol\u00e9culas de adhesi\u00f3n (galectina-3 y galectina-1, receptor de laminina de lata afinidad) en la progresi\u00f3n de tumores humanos"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Xavier SanJuan  Garriga <\/strong><\/h2>\n<p>El objeto de estudio es la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n celular receptor de laminina de 67 kda (67lr), galectina-1 y galectina-3 en el c\u00e1ncer colorrectal y diversos tipos de c\u00e1ncer tiroideo. Se ha analizado inmunohistoqu\u00edmicamente el 67 lr en mucosas col\u00f3nicas normales, adenomas, carcinomas colorrectales y met\u00e1stasis ganglionares. La expresi\u00f3n de 67 lr se correlaciona significativamente con la progresi\u00f3n desde la mucosa normal (22%) a los adenomas (44%), carcinomas (61%) y met\u00e1stasis ganglionares (75%). Se ha estudiado mediante inmunohistoqu\u00edmica y western-blot la expresi\u00f3n de galectina-1 y galectina-3 en el mismo tipo de lesiones colorrectales. la expresi\u00f3n nuclear intensa de galectina-3 disminuye en la progresi\u00f3n neopl\u00e1sica siendo positiva en todas las mucosas normales, 60% de los adenomas, 48% de los carcinomas y 44% de las met\u00e1stasis. Su expresi\u00f3n se asocia a diferenciaci\u00f3n celular. La expresi\u00f3n citopl\u00e1smica muy intensa de galectina-3 en los carcinomas se asocia a estadio tumoral avanzado y menor supervivencia. la expresi\u00f3n de galectina-1 en el c\u00e1ncer colorrectal se detecta en el estroma que acompa\u00f1a a la proliferaci\u00f3n epitelial y su sobreexpresi\u00f3n se correlaciona con la progresi\u00f3n tumoral desde la mucosa normal (12%) a los adenomas (40%) y carcinomas (84%). El estudio de la expresi\u00f3n de galectina-3 en lesiones tiroideas revela una intensa positivida inmunohistoqu\u00edmica en carcinomas papilares y menos intensa en carcionmas anapl\u00e1sicos. Los carcinomas foliculares, medulares e insulares muestran una positividad menor y focal.Las lesiones benignas y el tiroides normal son negativos para galectina-3. Estos resultados en tiroides son confirmados mediante northern-blot. En consecuencia, la galectina-3 permite el diagn\u00f3stico diferencial entre lesiones beningnas y malignas (especialmente el carcinoma papilar) del tiroides.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Expresi\u00f3n diferencial de mol\u00e9culas de adhesi\u00f3n (galectina-3 y galectina-1, receptor de laminina de lata afinidad) en la progresi\u00f3n de tumores humanos<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Expresi\u00f3n diferencial de mol\u00e9culas de adhesi\u00f3n (galectina-3 y galectina-1, receptor de laminina de lata afinidad) en la progresi\u00f3n de tumores humanos <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Xavier SanJuan  Garriga <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/09\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Cardesa Garc\u00eda<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: cristobal Pera blanco-morales <\/li>\n<li>Jos\u00e9 Mar\u00eda Corominas torres (vocal)<\/li>\n<li>sergio Serrano figueras (vocal)<\/li>\n<li>teresa Ribalta farres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Xavier SanJuan Garriga El objeto de estudio es la expresi\u00f3n de las mol\u00e9culas de adhesi\u00f3n celular receptor [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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