{"id":38668,"date":"1998-01-10T00:00:00","date_gmt":"1998-01-10T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/la-alfa-glutation-s-transferasa-gst-alfa-en-la-evaluacion-de-la-lesion-hepatica\/"},"modified":"1998-01-10T00:00:00","modified_gmt":"1998-01-10T00:00:00","slug":"la-alfa-glutation-s-transferasa-gst-alfa-en-la-evaluacion-de-la-lesion-hepatica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/la-alfa-glutation-s-transferasa-gst-alfa-en-la-evaluacion-de-la-lesion-hepatica\/","title":{"rendered":"La alfa glutati\u00f3n s-transferasa (gst-alfa) en la evaluaci\u00f3n de la lesi\u00f3n hep\u00e1tica"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Eva Girona Torres <\/strong><\/h2>\n<p>La valoraci\u00f3n bioqu\u00edmica de la lesi\u00f3n hep\u00e1tica que incluye la medici\u00f3n en suero de las transaminasas convencionales tiene sus limitaciones, sobre todo en la detecci\u00f3n de da\u00f1o hep\u00e1tico t\u00f3xico debido a su distribuci\u00f3n predominante en los hepatocitos periportales y no en los centrolobulillares que son m\u00e1s sensibles a esta noxa. En este sentido, la gst-alfa podr\u00eda constituir un marcador superior a las transaminasas en la evaluaci\u00f3n de la lesi\u00f3n hep\u00e1tica, debido a su distribuci\u00f3n homog\u00e9nea y a elevadas concentraciones en el lobulillo hep\u00e1tico. Los objetivos planteados en la presente memoria son:  1,- demostrar que la gst-alfa detecta m\u00e1s precozmente y con mayor sensibildiad que la biolog\u00eda hep\u00e1tica convencional la lesi\u00f3n hep\u00e1tica inducida por paracetamol en ratones.  2,- evaluar la gst-alfa en la monitorizaci\u00f3n de la lesi\u00f3n hep\u00e1tica en pacientes sometidos a tartamiento antituberculoso, compar\u00e1ndola con los marcadores habituales de depatotoxicidad.  3,- evaluar la gst-alfa en pacientes afectos de hepatitis cr\u00f3nica por vhc en tratamiento con interferon, en comparaci\u00f3n con las pruebas hep\u00e1ticas convencionales.  4,- establecer la utilidad de la gst-alfa como marcador de etiol\u00f3gia alcoh\u00f3lica en la pancreatitis aguda.  el estudio consta de dos protocolos. Uno experimental que incluye a 46 ratones, a los que se inyectan dosis subt\u00f3cias y crecientes de pracetamol intraperitoneal (100 y 200 mg\/kg), procediendo posteriormente a su sacrificio a las 6 y 24 horas tras la administraci\u00f3n, determinando los niveles plasm\u00e1ticos de gst-alfa y gpt, as\u00ed como el grado de lesi\u00f3n histol\u00f3gica. Y uno cl\u00ednico, que incluye a tres grupos de pacientes:  grupo i (n=20): en el que se comparan de forma seriada, los niveles s\u00e9ricos de gst-alfa y transaminasas de pacientes sometidos a tratamiento antituberculoso.  grupo ii (n=13): que incluye a pacientes con hepatitis cr\u00f3nica por vhc sometidos a tratamiento con interferon, en el<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>La alfa glutati\u00f3n s-transferasa (gst-alfa) en la evaluaci\u00f3n de la lesi\u00f3n hep\u00e1tica<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 La alfa glutati\u00f3n s-transferasa (gst-alfa) en la evaluaci\u00f3n de la lesi\u00f3n hep\u00e1tica <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Eva Girona Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Miguel hern\u00e1ndez de elche<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/10\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Miguel Perez Mateo Regadera<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Merino sanchez <\/li>\n<li> Rodrigo g\u00f3mez Jos\u00e9 Manuel (vocal)<\/li>\n<li>Rafael Calpena rico (vocal)<\/li>\n<li>Carlos Guarner aguilar (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Eva Girona Torres La valoraci\u00f3n bioqu\u00edmica de la lesi\u00f3n hep\u00e1tica que incluye la medici\u00f3n en suero de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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