{"id":38715,"date":"2018-03-09T09:38:25","date_gmt":"2018-03-09T09:38:25","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/psicofarmacologia-de-la-esclerosis-multiple\/"},"modified":"2018-03-09T09:38:25","modified_gmt":"2018-03-09T09:38:25","slug":"psicofarmacologia-de-la-esclerosis-multiple","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/psicofarmacologia-de-la-esclerosis-multiple\/","title":{"rendered":"Psicofarmacolog\u00eda de la esclerosis multiple."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Dolores Pereiro Raposo <\/strong><\/h2>\n<p>La esclerosis m\u00faltiple es una de las enfermedades desmielinizantes del snc que de forma m\u00e1s com\u00fan afecta a adultos j\u00f3venes, entre los 20 y los 40 a\u00f1os, lo que implica graves consecuencias sociales y econ\u00f3micas. Dada la repercusi\u00f3n de esta enfermedad, se han realizado muchos esfuerzos dirigidos no s\u00f3lo al conocimiento de sus causas y\/o agentes desencadenantes, sin\u00f3 tambi\u00e9n a desarrollar nuevas estrategias terap\u00e9uticas.  su etiolog\u00eda est\u00e1 asociada a diversidad de factores gen\u00e9ticos y ambientales. Es posible, que una combinaci\u00f3n de factores ambientales en un hu\u00e9sped susceptible puedan conducir al desarrollo de la enfermedad. Entre dichos factores, se incluyen agentes ex\u00f3genos de car\u00e1cter infeccioso o estresante. durante los \u00faltimos a\u00f1os, diferentes estudios cl\u00ednicos y experimentales apuntan hacia un posible papel de agentes o situaciones estresantes concretas en la aparici\u00f3n o evoluci\u00f3n de la esclerosis m\u00faltiple, posiblemente perturbando un sistema neuroinmunol\u00f3gico ya alterado.  el trabajo experimental presentado en esta tesis ha sido realizado con el fin de confirmar la participaci\u00f3n del estr\u00e9s en la etiopatogenia de la eae (encefalitis experimental autoinmune), enfermedad autoinmune inducida en ratas susceptibles que es equiparable a la esclerosis m\u00faltiple de los humanos. Tras inducir la enfermedad hemos verificado si la atenuaci\u00f3n de la ansiedad generada por el estr\u00e9s sonoro, mediante f\u00e1rmacos ansiol\u00edticos permite disminuir la sintomatolog\u00eda de la eae. En sentido opuesto, tambi\u00e9n hemos comprobado si la inducci\u00f3n de una respuesta ansiosa, mediante la administraci\u00f3n de sustancias ansiog\u00e9nicas, pod\u00eda exacerbar la sintomatolog\u00eda de la eae.  los hallazgos derivados de esta tesis demuestran que la ansiedad generada por el estr\u00e9s sonoro y f\u00e1rmacos psicoestimulantes incrementan la severidad de los s\u00edntomas neurol\u00f3gicos y el infiltrado inflamatorio perivascular, con respecto a los animales contr<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Psicofarmacolog\u00eda de la esclerosis multiple.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Psicofarmacolog\u00eda de la esclerosis multiple. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Dolores Pereiro Raposo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/10\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Nu\u00f1ez Manuel Freire Gacabal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Francisco Gonz\u00e1lez ru\u00edz <\/li>\n<li>Juan  Antonio Suarez quintanilla (vocal)<\/li>\n<li>Francisco Javier De toro santos (vocal)<\/li>\n<li>Luis Alberto Garcia vallejo (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Dolores Pereiro Raposo La esclerosis m\u00faltiple es una de las enfermedades desmielinizantes del snc que de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,2445,957,977],"tags":[2776,21055,35029,100314,100312,100313],"class_list":["post-38715","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-evaluacion-de-farmacos","category-farmacologia","category-santiago-de-compostela","tag-francisco-gonzalez-ruiz","tag-francisco-javier-de-toro-santos","tag-juan-antonio-suarez-quintanilla","tag-luis-alberto-garcia-vallejo","tag-m-dolores-pereiro-raposo","tag-nunez-manuel-freire-gacabal"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38715"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38715\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}