{"id":38723,"date":"2018-03-09T09:38:26","date_gmt":"2018-03-09T09:38:26","guid":{"rendered":""},"modified":"2018-03-09T09:38:26","modified_gmt":"2018-03-09T09:38:26","slug":"vasculitis-leucocitoclastica-estudio-de-factores-pronosticos-expresion-de-moleculas-de-adhesion-celular-y-de-activacion-endotelial-en-lesiones-cutaneas-ensayo-terapeutico-controlado-con-colchicina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/vasculitis-leucocitoclastica-estudio-de-factores-pronosticos-expresion-de-moleculas-de-adhesion-celular-y-de-activacion-endotelial-en-lesiones-cutaneas-ensayo-terapeutico-controlado-con-colchicina\/","title":{"rendered":"Vasculitis leucocitocl\u00e1stica. estudio de factores pron\u00f3sticos. expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n celular y de activaci\u00f3n endotelial en lesiones cutaneas. ensayo terap\u00e9utico controlado con colchicina oral."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Gemma Sais Puigdemont <\/strong><\/h2>\n<p>Para identificar factores de riesgo de evoluci\u00f3n cr\u00f3nica\/afectaci\u00f3n sistem\u00e1tica se llev\u00f3 a cabo un estudio cl\u00ednicopatol\u00f3gico en 160 pacientes con vasculitis leucocitocl\u00e1stica, realiz\u00e1ndose an\u00e1lisis uni\/multivarido mediante m\u00e9todo de regresi\u00f3n log\u00edstica. 89 mujeres y 71 varones, de edades comprendias entre 14 y 89 a\u00f1os se incluyeron en el estudio. En 20% de los casos se document\u00f3 afectaci\u00f3n sist\u00e9mica por vasculitis. En 21% de los pacientes se detectaron p-anca y en 25,4%, crioglobulinemia. S\u00f3lo el 1,9% de los pacientes falleci\u00f3 debido a su enfermedad vascul\u00edtica. La duraci\u00f3n media de las lesiones cutaneas fue 27,9 meses. En 67,2% un posible agente causal o enfermedad asociada fue indentificada. En el 56,9% de las biop0sias cutaneas la enfermedad se limitaba a los vasos de menor calibre del dermis superficial. el estudio de inmunofluorescencia directa result\u00f3 positivo en 84,3% de los casos. En el an\u00e1lisis multivariado se identificaron como factores de riesgo de afectaci\u00f3n sist\u00e9mica: las parestesias, la fibre y la ausencia de lesiones cutaneas dolorosas; y como factores de riesgo de evoluci\u00f3n cr\u00f3nica, la crioglobulinemia, las artralgias y la ausencia de fiebre.  en 42 lesiones de vasculitis leucocitocl\u00e1stica cutanea se realiz\u00f3 un estudio inmunohistoqu\u00edmico (estreptavidina-biotina-peroxidasa) para analizar la expresi\u00f3n secuencial de diversas mol\u00e9culas de adhesi\u00f3n a nivel endotelial y leucocitario. Se observ\u00f3 hiperexpresi\u00f3n de vla-1, hla-dr, y icam-1 a nivel endotelial, en comparaci\u00f3n a piel sana. La inducci\u00f3n de e-selectina endotelial en las lesiones de vasculitis era m\u00e1s marcada en las lesiones menos evolucionadas y estaba corrlacionada con la proproci\u00f3n de neutr\u00f3filos en el infiltrado.  la expresi\u00f3n de vcam-1 endotelilal se limitaba a lesiones m\u00e1s evolucionada. la mayor\u00eda de c\u00e9lulas  del infiltrado inflamatorio correspond\u00edan a neutr\u00f3filos que expresaban mac-1. Se document\u00f3 tambi\u00e9n un aumento d<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Vasculitis leucocitocl\u00e1stica. estudio de factores pron\u00f3sticos. expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n celular y de activaci\u00f3n endotelial en lesiones cutaneas. ensayo terap\u00e9utico controlado con colchicina oral.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Vasculitis leucocitocl\u00e1stica. estudio de factores pron\u00f3sticos. expresi\u00f3n de mol\u00e9culas de adhesi\u00f3n celular y de activaci\u00f3n endotelial en lesiones cutaneas. ensayo terap\u00e9utico controlado con colchicina oral. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Gemma Sais Puigdemont <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 22\/10\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jorge Peyri Rey<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: antoni Castells rodellas <\/li>\n<li>isidro Ferrer abizanda (vocal)<\/li>\n<li>carmen Herrero mateu (vocal)<\/li>\n<li>miquel Vilardell tarres (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Gemma Sais Puigdemont Para identificar factores de riesgo de evoluci\u00f3n cr\u00f3nica\/afectaci\u00f3n sistem\u00e1tica se llev\u00f3 a cabo un [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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