{"id":38844,"date":"2018-03-09T09:38:36","date_gmt":"2018-03-09T09:38:36","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-tisular-y-molecular-de-antigenos-hla-de-clase-i-clasicos-en-tumores-humanos\/"},"modified":"2018-03-09T09:38:36","modified_gmt":"2018-03-09T09:38:36","slug":"estudio-tisular-y-molecular-de-antigenos-hla-de-clase-i-clasicos-en-tumores-humanos","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-tisular-y-molecular-de-antigenos-hla-de-clase-i-clasicos-en-tumores-humanos\/","title":{"rendered":"Estudio tisular y molecular de antigenos hla de clase i clasicos en tumores humanos."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Angustias Fernandez Pineda <\/strong><\/h2>\n<p>Los ant\u00edgenos del complejo mayor de histocompatibilidad, conocidos como hla en el hombre constituyen los productos de un conjunto de genes situados en el brazo corto del cromosoma 6, que dan origen al sistema ant\u00edgeno m\u00e1s polim\u00f3rfico que existe en humanos. La funci\u00f3n de estos ant\u00edgenos hla consiste en la presentaci\u00f3n de p\u00e9ptidos ant\u00edgenos a los linfocitos t. Las mol\u00e9culas hla de clase i presentan p\u00e9ptidos, generalmente de origen end\u00f3geno, como pueden ser p\u00e9ptidos virales o tumorales, procesados en el interior de la c\u00e9lula a los linfocitos tcd8, especialmente a los ctls (linfocitos t citot\u00f3xicos). Es conocido desde hace tiempo que la expresi\u00f3n de ant\u00edgenos hla de clase i est\u00e1 alterada en tumores. Dado el papel central de dichos ant\u00edgenos en el reconocimiento y presentaci\u00f3n ant\u00edgenica, (los linfocitos t s\u00f3lo reconocen al ant\u00edgeno en el contexto de las mol\u00e9culas hla), este fen\u00f3meno puede suponer un mecanismo por parte de las c\u00e9lulas malignas para escapar de la inmunovigilancia. El estudio de las alteraciones de la expresi\u00f3n de ant\u00edgenos hla en tumores ha ido avanzado con la disponibilidad de anticuerpos monoclonales (acmos) que reconozcan diferentes ep\u00edtopos conformacionales de estas mol\u00e9culas. As\u00ed en la d\u00e9cada de los 70, se pod\u00edan detectar p\u00e9rdidas totales de ant\u00edgenos hla gracias a la existencia de acmos contra determinantes monom\u00f3rficos. En la d\u00e9cada de los 80, aparecieron acmos espec\u00edficos de locus que permit\u00edan detectar p\u00e9rdidas a este nivel, y en estos \u00faltimos a\u00f1os han aparecido acmos frente a especificidades al\u00e9licas. Nuestro grupo de investigaci\u00f3n, bas\u00e1ndose en estudios inmunohistoqu\u00edmicos y de biolog\u00eda molecular ha propuesto la siguiente clasificaci\u00f3n de fenotipos hla alterados en tumores: fenotipo i, cuando existe p\u00e9rdida total de expresi\u00f3n de ant\u00edgenos hla, fenotipo ii, cuando existe p\u00e9rdida de haplotipo, fenotipo iii, que tiene lugar cuando existe p\u00e9rdida de locus y<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio tisular y molecular de antigenos hla de clase i clasicos en tumores humanos.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio tisular y molecular de antigenos hla de clase i clasicos en tumores humanos. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Angustias Fernandez Pineda <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>puchol Garrido Torres<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>Jos\u00e9 Antonio Ferr\u00f3n orihuela (vocal)<\/li>\n<li>Antonio N\u00fa\u00f1ez rold\u00e1n (vocal)<\/li>\n<li>salvio Serrano ortega (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Angustias Fernandez Pineda Los ant\u00edgenos del complejo mayor de histocompatibilidad, conocidos como hla en el hombre [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,35,1737,2612],"tags":[35286,100529,100531,2167,3757,3671],"class_list":["post-38844","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-ciencias-de-la-vida","category-inmunologia","category-inmunoquimica","tag-antonio-nunez-roldan","tag-jose-antonio-ferron-orihuela","tag-m-angustias-fernandez-pineda","tag-miguel-morell-ocana","tag-puchol-garrido-torres","tag-salvio-serrano-ortega"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38844"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38844\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}