{"id":38845,"date":"2018-03-09T09:38:37","date_gmt":"2018-03-09T09:38:37","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/beta-glucuronidasa-y-glucosaminoglicanos-urinarios-en-el-diagnostico-de-la-nefropatia-diabetica\/"},"modified":"2018-03-09T09:38:37","modified_gmt":"2018-03-09T09:38:37","slug":"beta-glucuronidasa-y-glucosaminoglicanos-urinarios-en-el-diagnostico-de-la-nefropatia-diabetica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/beta-glucuronidasa-y-glucosaminoglicanos-urinarios-en-el-diagnostico-de-la-nefropatia-diabetica\/","title":{"rendered":"Beta-glucuronidasa y glucosaminoglicanos urinarios en el diagnostico de la nefropatia diabetica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Tomas Mu\u00f1oz Casaubon <\/strong><\/h2>\n<p>En la diabetes mellitus se conoce que el aumento de la presi\u00f3n intraglomerular produce una alteraci\u00f3n de la selectividad de carga a nivel de la membrana basal glomerular, activ\u00e1ndose los enzimas lisos\u00f3micos n-acetil-beta-glucosaminidasa y beta-glucuronidasa que degradan las mol\u00e9culas de glucosaminoglicanos que forman parte de la mbg quedando deficitaria de estos y perdiendo su carga el\u00e9ctrica negativa. De esta forma se incrementa el filtrado glomerular de alb\u00famina. El final del proceso ser\u00eda el aumento del tama\u00f1o de los poros de la mbg, perpetuando la presencia patol\u00f3gica de alb\u00famina por la orina.  por tanto en el desarrollo inicial de la lesi\u00f3n renal del paciente diab\u00e9tico intervienen de forma importante los glucosaminoglicanos, que se pueden medir en su excreci\u00f3n urinaria, y los enzimas encargados de su catabolismo, siendo uno de los m\u00e1s importantes la beta-glucuronidasa.  proponemos cuantificar la excreci\u00f3n urinaria de gag y la actividad urinaria de la beta-glucuronidasa en 130 pacientes diab\u00e9ticos que hemos agrupado atendiendo al grado de afectaci\u00f3n renal siguiendo la clasificaci\u00f3n de mogensen. como grupo control se estudiaron 64 sanos. Se descartaron los enfermos con nefropat\u00eda de otra \u00edndole, infecci\u00f3n urinaria o hipertensi\u00f3n arterial que no fueran diab\u00e9ticos y los que realizaban tratamiento con ieca.  la determinaci\u00f3n de beta-glucuronidasa se realiz\u00f3 en orina de 24 horas siguiendo el m\u00e9todo basado en la hidr\u00f3lisis enzim\u00e1tica de goldbarg y la de gag por el m\u00e9todo colorim\u00e9trico de pennock.  se realiz\u00f3 estudio estad\u00edstico descriptivo para los diferentes grupos. Se comprob\u00f3 la normalidad de las variables cuantitativas mediante el test de kolgonorow-smirnoff. En los diferentes grupos se realiz\u00f3 el test de comparaci\u00f3n de medias o el an\u00e1lisis de la varianza para una v\u00eda y los test no param\u00e9tricos cuando las variables no se ajustaban a la normalidad. Se acept\u00f3 las distintas variable<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Beta-glucuronidasa y glucosaminoglicanos urinarios en el diagnostico de la nefropatia diabetica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Beta-glucuronidasa y glucosaminoglicanos urinarios en el diagnostico de la nefropatia diabetica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Tomas Mu\u00f1oz Casaubon <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 20\/11\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Blanco<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Gomez capilla <\/li>\n<li>Manuel Martin gonzalez (vocal)<\/li>\n<li>Antonio Mu\u00f1oz hoyos (vocal)<\/li>\n<li>Jos\u00e9 Vicente rull (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Tomas Mu\u00f1oz Casaubon En la diabetes mellitus se conoce que el aumento de la presi\u00f3n intraglomerular produce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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