{"id":38867,"date":"2018-03-09T09:38:39","date_gmt":"2018-03-09T09:38:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/niveles-de-leptina-en-relacion-con-la-composicion-corporal-y-el-sistema-gh-igf-i-igfbp-3-en-el-hiper-e-hiposomatotropismo\/"},"modified":"2018-03-09T09:38:39","modified_gmt":"2018-03-09T09:38:39","slug":"niveles-de-leptina-en-relacion-con-la-composicion-corporal-y-el-sistema-gh-igf-i-igfbp-3-en-el-hiper-e-hiposomatotropismo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/niveles-de-leptina-en-relacion-con-la-composicion-corporal-y-el-sistema-gh-igf-i-igfbp-3-en-el-hiper-e-hiposomatotropismo\/","title":{"rendered":"Niveles de leptina en relacion con la composicion corporal y el sistema  gh\/igf-i\/igfbp-3 en el hiper e hiposomatotropismo."},"content":{"rendered":"<h2>Tesis doctoral de <strong> M. Concepcion Paramo Fernandez <\/strong><\/h2>\n<p>El presente trabajo eval\u00faa los niveles plasm\u00e1ticos de leptina en relaci\u00f3n con los cambios en la composici\u00f3n corporal y en el sistema somatotropo, gh\/igf-i\/igfbp-3, provocados por la acromegalia y el d\u00e9ficit de gh, como modelos de hipersecreci\u00f3n e hiposecreci\u00f3n cr\u00f3nica de gh respectivamente, comparando los hallazgos de ambos grupos entre s\u00ed y con un grupo control con eje somatotropo normal. Adicionalmente se analiza el papel de la composici\u00f3n corporal y de la leptina en el manejo de los pacientes con acromegalia.  se estudiaron cuatro grupos de sujetos: acromegalia inactiva (n=15), acromegalia con actividad cl\u00ednica (n= 19), d\u00e9ficit de gh (n= 44) y control (n= 43). Las determinaciones realizadas fueron: antropometr\u00eda, estimaci\u00f3n neta y porcentual de la masa magra, masa grasa, agua corporal total y agua extracelular mediante bioimpedanciometr\u00eda multifrecuencia y determinaciones hormonales basales de gh, igf-i, igfbp-3 y leptina.  la hipersecreci\u00f3n cr\u00f3nica de gh condicion\u00f3 un incremento de los contenidos netos y porcentuales de masa magra, agua corporal total y agua extracelular, y disminuci\u00f3n de la masa grasa mientras que el d\u00e9ficit de gh mostr\u00f3 cambios en sentido opuesto.  el igf-i fue el par\u00e1metro del eje somatotropo que mejor discrimin\u00f3 entre los distintos grupos de estudio, siendo mayor en acromeg\u00e1licos y menor en deficitarios de gh, con el grupo control situado en niveles intermedios.  la leptina, al igual que la composici\u00f3n corporal, mostr\u00f3 una marcado dimorfismo sexual en todos los grupos de estudio, variando sus concentraciones plasm\u00e1ticas en sentido inverso a los valores del eje somatotropo. esta interacci\u00f3n, podr\u00eda deberse m\u00e1s que a un efecto directo a los cambios en el compartimento graso asociados a los distintos estados secretores de gh. En el an\u00e1lisis de regresi\u00f3n m\u00faltiple la masa grasa fue la variable que mostr\u00f3 un mayor poder predictivo sobre los niveles plasm\u00e1ticos de l<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Niveles de leptina en relacion con la composicion corporal y el sistema  gh\/igf-i\/igfbp-3 en el hiper e hiposomatotropismo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Niveles de leptina en relacion con la composicion corporal y el sistema  gh\/igf-i\/igfbp-3 en el hiper e hiposomatotropismo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 M. Concepcion Paramo Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>F. Casanueva<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Dieguez gonzalez <\/li>\n<li>Luis felipe Pallardo sanchez (vocal)<\/li>\n<li>Mar\u00eda  ausencia Tom\u00e9 Martinez de rituerto (vocal)<\/li>\n<li>tom\u00e1s Lucas morante (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de M. Concepcion Paramo Fernandez El presente trabajo eval\u00faa los niveles plasm\u00e1ticos de leptina en relaci\u00f3n con los [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,851,817,977],"tags":[15487,100572,14834,100571,99205,37248],"class_list":["post-38867","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-endocrinologia","category-fisiologia-humana","category-santiago-de-compostela","tag-carlos-dieguez-gonzalez","tag-f-casanueva","tag-luis-felipe-pallardo-sanchez","tag-m-concepcion-paramo-fernandez","tag-maria-ausencia-tome-Martinez-de-rituerto","tag-tomas-lucas-morante"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38867"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38867\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38867"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38867"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}