{"id":38869,"date":"2018-03-09T09:38:39","date_gmt":"2018-03-09T09:38:39","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/regulacion-de-la-secrecion-de-gh-por-la-ghrh-y-el-ghrp6-en-la-dm1\/"},"modified":"2018-03-09T09:38:39","modified_gmt":"2018-03-09T09:38:39","slug":"regulacion-de-la-secrecion-de-gh-por-la-ghrh-y-el-ghrp6-en-la-dm1","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/regulacion-de-la-secrecion-de-gh-por-la-ghrh-y-el-ghrp6-en-la-dm1\/","title":{"rendered":"Regulacion de la secrecion de gh por la ghrh y el ghrp6 en la dm1."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pablo Fern\u00e1ndez Catalina <\/strong><\/h2>\n<p>Las alteraciones del eje somatotropo en la diabetes mellitus (dm) han suscitado m\u00faltiples controversias acerca de su origen y posibles repercusiones fisiopatol\u00f3gicas. en individuos diagnosticados de dm tipo 1 (dm 1) las concentraciones plasm\u00e1ticas basales de gh, as\u00ed como su respuesta ante diversos est\u00edmulos se hallan elevadas.  el objetivo fundamental de este trabajo ha sido tratar de esclarecer si tales aumentos son debidos o no a un estado de hipersecreci\u00f3n glandular hipofisaria.  en primer lugar, estudiamos la respuesta de las concentraciones plasm\u00e1ticas de gh en 6 varones adultos diagnosticados de dm 1 y 6 individuos sanos, apareados por sexo, edad e \u00edndice de masa corporal (imc). A todos ellos les administramos 100 ug de ghrh, 90 mg de ghrp-6 o la suma de ambos, en forma de bolo i.V., En 3 d\u00edas diferentes. Antes de la administraci\u00f3n del est\u00edmulo se extrajeron muestras de sangre venosa para la determinaci\u00f3n de las cifras plasm\u00e1ticas de igf-1 e igfbp-3. Efectuamos mediciones de las concentraciones plasm\u00e1ticas de gh en diferentes tiempos, empleando un ensayo inmunorradiom\u00e9trico de elevada sensibilidad. El an\u00e1lisis estad\u00edstico de los datos se realiz\u00f3 con pruebas no param\u00e9tricas. De este modo, pudimos observar que las concentraciones s\u00e9ricas de gh fueron mayores en el grupo de pacientes con cada uno de los tres est\u00edmulos empleados. Adem\u00e1s la administraci\u00f3n conjunta de ghrh y ghrp-6 desencaden\u00f3 una mayor respuesta en ambos grupos que su administraci\u00f3n por separado. Los niveles plasm\u00e1ticos basales resultaron menores en el grupo de diab\u00e9ticos, mientras que las cifras de igfbp-3 no arrojaron diferencias significativas entre ambos grupos. De esto \u00faltimo se deduce que la fracci\u00f3n libre de igf-1 es menor en los pacientes con dm 1.  posteriormente, evaluamos la cin\u00e9tica de eliminaci\u00f3n hormonal de gh en un grupo de 6 varones adultos con dm 1 y 6 voluntarios sanos. Tras la supresi\u00f3n previa de la producci<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Regulacion de la secrecion de gh por la ghrh y el ghrp6 en la dm1.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Regulacion de la secrecion de gh por la ghrh y el ghrp6 en la dm1. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pablo Fern\u00e1ndez Catalina <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 27\/11\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Federico Mallo Ferrer<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: felipe Casanueva feijoo <\/li>\n<li>ramon Gomis de barbar? (vocal)<\/li>\n<li>ricardo victor Garcia  garcia-mayor (vocal)<\/li>\n<li>Fernando Cordido carballido (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pablo Fern\u00e1ndez Catalina Las alteraciones del eje somatotropo en la diabetes mellitus (dm) han suscitado m\u00faltiples controversias [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,851,817,977],"tags":[54291,86893,57004,100574,1375,100575],"class_list":["post-38869","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-endocrinologia","category-fisiologia-humana","category-santiago-de-compostela","tag-federico-mallo-ferrer","tag-felipe-casanueva-feijoo","tag-fernando-cordido-carballido","tag-pablo-fernandez-catalina","tag-ramon-gomis-de-barbar","tag-ricardo-victor-garcia-garcia-mayor"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=38869"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/38869\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=38869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=38869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=38869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}