{"id":38894,"date":"1998-02-12T00:00:00","date_gmt":"1998-02-12T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/modulacion-de-la-aterotrombosis-mediante-inhibidores-de-la-3-hidroxi-3-metilglutaril-coenzima-a-reductasa\/"},"modified":"1998-02-12T00:00:00","modified_gmt":"1998-02-12T00:00:00","slug":"modulacion-de-la-aterotrombosis-mediante-inhibidores-de-la-3-hidroxi-3-metilglutaril-coenzima-a-reductasa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/modulacion-de-la-aterotrombosis-mediante-inhibidores-de-la-3-hidroxi-3-metilglutaril-coenzima-a-reductasa\/","title":{"rendered":"Modulaci\u00f3n de la aterotrombosis mediante inhibidores de la 3-hidroxi-3-metilglutaril coenzima a reductasa"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Jos\u00e9 Alberto Alfon Coriat <\/strong><\/h2>\n<p>Los ensayos cl\u00ednicos han demostrado que el tratamiento hipolipemiante con estatinas reduce la mortalidad asociada con la cardiopat\u00eda isqu\u00e9mica. no obstante, es dif\u00edcil asociar todo el beneficio terap\u00e9utico observado con la reducci\u00f3n de los niveles plasm\u00e1ticos de l\u00edpidos. Se ha estudiado en dos modelos animales (cerdo y conejo) la aterosclerosis el efecto de varias estatinas (atorvastatina, pravastatina y simvastatina) en el desarrollo de la lesi\u00f3n vascular y en la trombosis plaquetar inducida por lesiones vasculares. Se ha observado una reducci\u00f3n de la formaci\u00f3n de estr\u00edas grasa, la cual es dependiente de la reducci\u00f3n de los l\u00edpidos plasm\u00e1ticos. Sin embargo, la reducci\u00f3n del engrosamiento de la \u00edntima no se asoci\u00f3 con la reducci\u00f3n de los niveles plasm\u00e1ticos de l\u00edpidos. La inducci\u00f3n del gen mcp-1 se redujo con el tratamiento farmacol\u00f3gico, s\u00f3lo cuando la hiperlipemia fue moderada. La inducci\u00f3n del gen nos ii se asoci\u00f3 con el engrosamiento de la \u00edntima. La atorvastatina redujo el dep\u00f3sito de plaquetas cuando se perfundi\u00f3 un sustrato vascular con lesi\u00f3n ligera a alta velocidad de cizalladura, lo cual sugiere un mecanismo ligado al receptor gpib. Esta pasivaci\u00f3n de las plaquetas puede suponer un mecanismo protector frente a la trombosis asociada a la erosi\u00f3n de la pared vascular.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modulaci\u00f3n de la aterotrombosis mediante inhibidores de la 3-hidroxi-3-metilglutaril coenzima a reductasa<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modulaci\u00f3n de la aterotrombosis mediante inhibidores de la 3-hidroxi-3-metilglutaril coenzima a reductasa <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Jos\u00e9 Alberto Alfon Coriat <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 02\/12\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Lina Badimon Maestro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Bages de luna <\/li>\n<li>Emilio Ros rahola (vocal)<\/li>\n<li>Carlos Villaverde grote (vocal)<\/li>\n<li>Juan  Carlos Laguna egea (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Jos\u00e9 Alberto Alfon Coriat Los ensayos cl\u00ednicos han demostrado que el tratamiento hipolipemiante con estatinas reduce la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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