{"id":38967,"date":"2018-03-09T09:38:49","date_gmt":"2018-03-09T09:38:49","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/desarrollo-y-aplicaciones-de-tres-metodologias-sinteticas-sobre-dihidropiridinas\/"},"modified":"2018-03-09T09:38:49","modified_gmt":"2018-03-09T09:38:49","slug":"desarrollo-y-aplicaciones-de-tres-metodologias-sinteticas-sobre-dihidropiridinas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/desarrollo-y-aplicaciones-de-tres-metodologias-sinteticas-sobre-dihidropiridinas\/","title":{"rendered":"Desarrollo y aplicaciones de tres metodolog\u00edas sinteticas sobre dihidropiridinas"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Gullon Lopez <\/strong><\/h2>\n<p>La estrategia de adici\u00f3n nucle\u00f3fila a sales de piridino seguida de ciclaci\u00f3n, utilizada en la s\u00edntesisde alcaloides, ha sido extendida hacia la formaci\u00f3n de esqueletos de tipo aspidospermatano. La metodolog\u00eda consistente en la reducci\u00f3n de la dihidropiridina intemedia a una tetrahidropirdina y su posterior ciclaci\u00f3n sobre el doble enlace m\u00e1s sustituido es efectiva en dihidropiridinas de origen intramolecular.  la conversi\u00f3n formal en epoxidos de n-alquildihidropiridinas, en la formaci\u00f3n de dioxanos se ha conseguido con dimetildioxirano y constituye el primer ejemplo de ete tipo de transformaciones, permitiendo su uso sintetico, como demuestra la introducci\u00f3n de diferentes nucleofilos y la obtencion de 5-hidroxitetr4ahidropiridinas diversamente sustituidas en la posicion 6.  la aproximaci\u00f3n intramolecular permite el desarrollo de la metodolog\u00eda de adici\u00f3n nucleofila a sales de piridino 3,5-disustituidas. La aplicaci\u00f3n de este proceso a la ciclaci\u00f3n de una enamida y obtenci\u00f3n de un intermedio pentaciclico permite el planteamiento de una estrategia sint\u00e9tica de los alcaloides de la familia vallesiacotamano por introducci\u00f3n de los diferentes sustituyentes mediante la quimica del paladio.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Desarrollo y aplicaciones de tres metodolog\u00edas sinteticas sobre dihidropiridinas<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Desarrollo y aplicaciones de tres metodolog\u00edas sinteticas sobre dihidropiridinas <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Gullon Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 15\/12\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Rodolfo Lavilla Grifols<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: gregorio Asensio aguilar <\/li>\n<li>mercedes Amat tus\u00f3n (vocal)<\/li>\n<li>Miguel \u00e1ngel Peric\u00ed\u00a0s brondo (vocal)<\/li>\n<li>amadeu Llebaria soldevila (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Gullon Lopez La estrategia de adici\u00f3n nucle\u00f3fila a sales de piridino seguida de ciclaci\u00f3n, utilizada en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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