{"id":39025,"date":"2018-03-09T09:38:55","date_gmt":"2018-03-09T09:38:55","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efectos-del-captopril-y-enalapril-en-dos-modelos-experimentales-de-diabetes-mellitus\/"},"modified":"2018-03-09T09:38:55","modified_gmt":"2018-03-09T09:38:55","slug":"efectos-del-captopril-y-enalapril-en-dos-modelos-experimentales-de-diabetes-mellitus","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efectos-del-captopril-y-enalapril-en-dos-modelos-experimentales-de-diabetes-mellitus\/","title":{"rendered":"Efectos del captopril y enalapril en dos modelos experimentales de diabetes mellitus."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Andres Martinez Maraver <\/strong><\/h2>\n<p>Se realiza un estudio comparativo de los efectos de dos inhibidores de la enzima de conversi\u00f3n de la angiotensina (ieca), captopril y enalapril, en dos modelos experimentales de diabetes mellitus: a) ratas obesas zucker, animal que presenta hiperinsulinemia, resistencia a la insulina e intolerancia a la glucosa y b) ratas diab\u00e9ticas por estreptozotocina.  1.- Evaluando los efectos del tratamiento con dichos f\u00e1rmacos:  &#8211; sobre el metabolismo gluc\u00eddico, determinando los niveles de glucemia e insulinemia, el contenido de insulina, adn y prote\u00ednas en p\u00e1ncreas, y la captaci\u00f3n de glucosa por el diafragma.  &#8211; sobre el metabolismo lip\u00eddico y pur\u00ednico, se determina colesterol total, hdl-colesterol, triglic\u00e9rido totales y \u00e1cido \u00farico.  &#8211; a nivel renal se determina urea y creatinina en plasma, la excreci\u00f3n urinaria de prote\u00ednas y el \u00edndice de hipertrofia renal.  &#8211; sobre el estado oxidativo, se estudia la actividad antioxidante frente a 1,1 difenil 2- pierilhidracil (dpph), y la peroxidaci\u00f3n lip\u00eddica en h\u00edgado determinando niveles de malonildialdeh\u00eddo (mda), aldeh\u00eddo que tambi\u00e9n fue determinado en plasma.  2.- Estudiando los mecanismos implicados en la captaci\u00f3n de glucosa inducida por los ieca, para ello se incubaron los diafragmas con los f\u00e1rmacos en estudio, distintas concentraciones de bradikinina, su antagonista competitivo (b-7894) y un inhibidor de la tirosinkinasa del receptor de insulina como es la genisteina.  llegando a las siguientes conclusiones:  1) el tratamiento durante 14 d\u00edas con captopril o maleato de enalapril produjo, en ratas obesas zucker, una reducci\u00f3n de la glucemia, significativa para el grupo de animales tratados con captopril. Estos f\u00e1rmacos promueven la liberaci\u00f3n pancre\u00e1tica de insulina y la captaci\u00f3n muscular de glucosa, mejorando por tanto la resistencia perif\u00e9rica a la hormona.  2) en ratas obesas zucker los ieca produjeron una disminuci\u00f3n de la presi\u00f3n sist\u00f3lic<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efectos del captopril y enalapril en dos modelos experimentales de diabetes mellitus.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efectos del captopril y enalapril en dos modelos experimentales de diabetes mellitus. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Andres Martinez Maraver <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 18\/12\/1998<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>M\u00aa Paloma Cabo Cires<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Antonio Zarzuelo zurita <\/li>\n<li>Jos\u00e9 Mar\u00eda Calleja suarez (vocal)<\/li>\n<li>\u00e1ngel Villar del fresno (vocal)<\/li>\n<li>ricardo Vilchez joya (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Andres Martinez Maraver Se realiza un estudio comparativo de los efectos de dos inhibidores de la enzima [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,489,957,6530],"tags":[100864,4663,43629,2448,67967,19552],"class_list":["post-39025","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacognosia","category-farmacologia","category-farmacologia-experimental","tag-andres-Martinez-maraver","tag-angel-villar-del-fresno","tag-antonio-zarzuelo-zurita","tag-jose-maria-calleja-suarez","tag-ma-paloma-cabo-cires","tag-ricardo-vilchez-joya"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39025","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39025"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39025\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39025"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39025"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39025"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}