{"id":39154,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/papel-de-citoesqueleto-de-la-celula-acinar-pancreatica-en-la-secrecion-pancreatica-exocrina-y-en-la-pancreatitis-aguda\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"papel-de-citoesqueleto-de-la-celula-acinar-pancreatica-en-la-secrecion-pancreatica-exocrina-y-en-la-pancreatitis-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/papel-de-citoesqueleto-de-la-celula-acinar-pancreatica-en-la-secrecion-pancreatica-exocrina-y-en-la-pancreatitis-aguda\/","title":{"rendered":"Papel de citoesqueleto de la celula acinar pancreatica en la secrecion pancreatica exocrina y en la pancreatitis aguda."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Sans Gili M. Dolors <\/strong><\/h2>\n<p>Antecedentes y objetivo: el papel del citoesqueleto en la secreci\u00f3n pancre\u00e1tica exocrina y en la pancreatitis aguda no se ha podido establecer por el momento. Se ha sugerido que la disrupci\u00f3n del citoesqueleto podria ser el mecanismo desencadenante de la pancreatitis aguda. M\u00e9todos: se han analizado los cambios que induce la estimulaci\u00f3n con diferentes dosis de ceruleina a nivel del citoesqueleto de la c\u00e9lula acinar pancre\u00e1tica tanto in vivo como in vitro. se han utilizado agentes activos sobre el citoesqueleto y se han analizado los cambios a nivel morfol\u00f3gico utilizando t\u00e9cnicas de inmunofluorescencia, microscopia de esc\u00e1nning l\u00e1ser confocal y un an\u00e1lisis quantitativo de las im\u00e1genes. resultados: in vivo, la estimulaci\u00f3n con ceruleina a la dosis m\u00e1xima incrementa el marcage fluorescente de la beta-tubulina y de la actina-f. La ceruleina, a la dosis supram\u00e1xima causa un incremento de la fluorescencia de la actina-f basolateral, al tiempo que disminuye la fluorescencia emitida por beta-tubulina y por la actina-f apical. In vivo, la colchicina y la vinblastina causan una disrupci\u00f3n de lared de microt\u00fabulos, e inhiben la secreci\u00f3n pancre\u00e1tica exocrina estimulada pero no inducen pancreatitis aguda. In vitro, la administraci\u00f3n de taxol tambi\u00e9n inhibe la secreci\u00f3n de amilasa. Todos los agentes activos sobre el citoesqueleto disminuyeron el edema pancre\u00e1tico y el nmero de vacuolas autof\u00e1gicas en la pancreatitis aguda inducida por ceruleina, pero no revirtieron el bloqueo secretor. Conclusiones: se requiere la existencia de un citoesqueleto funcional par que puedan producirse los procesos de secreci\u00f3n pancre\u00e1tica exocrina y de pancreatitis aguda. los microfilamentos podrian estar implicados en el bloqueo secretor pero tambi\u00e9n podrian tener un papel protector evitando la extrusi\u00f3n de material citoplasm\u00e1tico. Los efectos beneficiosos de los agentes activos sobre los microt\u00fabulos sobre la pancreatitis<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Papel de citoesqueleto de la celula acinar pancreatica en la secrecion pancreatica exocrina y en la pancreatitis aguda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Papel de citoesqueleto de la celula acinar pancreatica en la secrecion pancreatica exocrina y en la pancreatitis aguda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Sans Gili M. Dolors <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Salvador Guillaumes Furnes<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: merce Durfort coll <\/li>\n<li>salvador Navarro colas (vocal)<\/li>\n<li>f\u00e9lix Llu\u00eds casaJuan a (vocal)<\/li>\n<li>adela Mazo sanchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Sans Gili M. Dolors Antecedentes y objetivo: el papel del citoesqueleto en la secreci\u00f3n pancre\u00e1tica exocrina y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[951,849,35,9,2008,156,1323],"tags":[33982,20461,14022,101096,20212,101095],"class_list":["post-39154","post","type-post","status-publish","format-standard","hentry","category-barcelona","category-biologia-celular","category-ciencias-de-la-vida","category-ciencias-medicas","category-morfologia-celular","category-patologia","category-patologia-experimental","tag-adela-mazo-sanchez","tag-felix-lluis-casajuan-a","tag-merce-durfort-coll","tag-salvador-guillaumes-furnes","tag-salvador-navarro-colas","tag-sans-gili-m-dolors"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39154"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39154\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}