{"id":39196,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/sintesis-de-nuevos-farmacos-relacionados-con-la-cascada-del-acido-araquidonico-compuestos-antagonistas-del-ltd4-e-inhibidores-selectivos-de-cox-2\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"sintesis-de-nuevos-farmacos-relacionados-con-la-cascada-del-acido-araquidonico-compuestos-antagonistas-del-ltd4-e-inhibidores-selectivos-de-cox-2","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/sintesis-de-nuevos-farmacos-relacionados-con-la-cascada-del-acido-araquidonico-compuestos-antagonistas-del-ltd4-e-inhibidores-selectivos-de-cox-2\/","title":{"rendered":"Sintesis de nuevos farmacos relacionados con la cascada del acido araquidonico: compuestos antagonistas del ltd4 e inhibidores selectivos de cox-2."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Berta Ballart Carbo <\/strong><\/h2>\n<p>El desarrollo de nuevos antiinflamatorios relacionados con la cascada del \u00e1cido araquid\u00f3nico es el tema central de dicho trabajo. en un primer cap\u00edtulo se dise\u00f1a una ruta sint\u00e9tica convergente para la s\u00edntesis de \u00e1cidos 4-(2-(7-heterociclometoxinaftal\u00e9n-2-ilmetoxi-etil) benz\u00f3icos, que posteriormente se valoran como antagonistas del ltd4.  aquellos derivados que contienen un tiazol substituido en la posici\u00f3n 4 por un grupo alquilo (ciclobutiloo isopropilo) presentan una buena actividad farmacol\u00f3gica, siendo de inter\u00e9s como compuestos antiasm\u00e1ticos.  en un segundo cap\u00edtulo se sintetizan an\u00e1logos de la flosulida o el ketoprofeno con el objetivo de hallar inhibidores selectivos del enzima cox-2, que actuen como antiinflamatorios no esteroideos. Su posterior evaluaci\u00f3n farmacol\u00f3gica confirma que, entre los muchos derivados sintetizados, el \u00e1cido 2-(5-benzoil-5-hidroxifenil) propi\u00f3nico presenta una inhibici\u00f3n potente y preferencial del enzima cox-2 en los ensayos farmacol\u00f3gicos realizados.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Sintesis de nuevos farmacos relacionados con la cascada del acido araquidonico: compuestos antagonistas del ltd4 e inhibidores selectivos de cox-2.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Sintesis de nuevos farmacos relacionados con la cascada del acido araquidonico: compuestos antagonistas del ltd4 e inhibidores selectivos de cox-2. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Berta Ballart Carbo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Lopez Calahorra<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: enrique Pedroso muller <\/li>\n<li>david Mauleon casellas (vocal)<\/li>\n<li>mercedes Alvarez domingo (vocal)<\/li>\n<li>Antonio Espinosa \u00fabeda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Berta Ballart Carbo El desarrollo de nuevos antiinflamatorios relacionados con la cascada del \u00e1cido araquid\u00f3nico es el [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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