{"id":39200,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estructura-tridimensional-de-la-proteasa-leader-del-virus-de-la-fiebre-aftosa\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estructura-tridimensional-de-la-proteasa-leader-del-virus-de-la-fiebre-aftosa","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/estructura-tridimensional-de-la-proteasa-leader-del-virus-de-la-fiebre-aftosa\/","title":{"rendered":"Estructura tridimensional de la proteasa leader del virus de la fiebre aftosa."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Alba Guarne Cabello <\/strong><\/h2>\n<p>Se ha determinado la estructura tridimensional de la forma lb de la proteasa leader del virus de la fiebre aftosa mediante cristalograf\u00eda de rayos x. La proteasa leader es la prote\u00edna codificada en el extremo aminoterminal de la poliprote\u00edna viral y tiene una funci\u00f3n doble, por un lado se autolibera de la poliprote\u00edna y posteriormente, inhibe la s\u00edntesis proteica de la c\u00e9lula hu\u00e9sped mediante el corte en el elf4g. Inicialmente, se determin\u00f3 por reemplazo isomorfo m\u00faltiple (mir) la estructura del mutante de delecci\u00f3n carboxiloterminal lbshort-c51a. Posteriormente, se determin\u00f3 por reemplazo molecular la estructura del mutante inactivo de longitud normal lb-c51a. La proteasa leader contiene una regi\u00f3n globular con la topolog\u00eda de las cisteinproteasas de la familia de la papa\u00edna y una extensi\u00f3n carboxiloterminal flexible. La estructura del mutante lb-c51a revela que el autoprocesamiento de la proteasa puede producirse en trans, aunque ciertos motivos estructurales indican que el procesamiento en cis tambi\u00e9n puede darse y adem\u00e1s informaci\u00f3n sobre los mecanismos moleculares que permiten que la proteasa leader pueda reconocer dos secuencias de corte distintas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estructura tridimensional de la proteasa leader del virus de la fiebre aftosa.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estructura tridimensional de la proteasa leader del virus de la fiebre aftosa. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Alba Guarne Cabello <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Barcelona<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Ignacio Fita Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Juan  Antonio Subirana torrent <\/li>\n<li>mauricio Garcia mateu (vocal)<\/li>\n<li>miquel Coll capella (vocal)<\/li>\n<li> Gomis ruth f. xavier (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Alba Guarne Cabello Se ha determinado la estructura tridimensional de la forma lb de la proteasa leader [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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