{"id":39251,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"valor-biologico-y-predictivo-de-recaida-del-seguimiento-molecular-mediante-estudio-del-qimerismo-hematopoyetico-con-vntr-pcr-y-deteccion-de-transcritos-bcr-abl-p210-p190-en-pacientes-trasplantados-de","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-biologico-y-predictivo-de-recaida-del-seguimiento-molecular-mediante-estudio-del-qimerismo-hematopoyetico-con-vntr-pcr-y-deteccion-de-transcritos-bcr-abl-p210-p190-en-pacientes-trasplantados-de\/","title":{"rendered":"Valor biologico y predictivo de recaida del seguimiento molecular mediante estudio del qimerismo hematopoyetico con vntr-pcr y deteccion de transcritos bcr-abl p210\/p190 en pacientes trasplantados de medula osea leucemia mieloide cronica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josefina Serrano Lopez <\/strong><\/h2>\n<p>La principal causa de fallo del trasplante en lmc es la recidiva de la enfermedad, cuya respuesta a tratamiento inmunomodulador parece depender del tama\u00f1o de la masa tumoral. Esto implicar\u00eda que el establecimiento de un grupo de pacientes con alto riesgo de reca\u00edda y la detecci\u00f3n precoz de la misma permitir\u00eda a dichos pacientes el poder beneficiarse de las ventajas de un tratamiento aplicado de forma precoz. Nos propusimos la monitorizaci\u00f3n conjunta de enfermedad m\u00ednima residual post-trasplante mediante el estudio semicuantitativo del quimerismo hematopoy\u00e9tico en sangre total y en subpoblaciones altamente purificadas (cd15, cd19, cd3 y cd56), as\u00ed como de marcadores tumorales p210\/p190 bcr-abl empleando rt-pcr en 60 pacientes (49 trasplantados con un injerto no manipulados y 11 con depleci\u00f3n selectiva de linfocitos t), con un seguimiento minimo de 12 meses. La progresi\u00f3n de la enfermedad que conduce a la reca\u00edda observada en 14 pacientes, objetivamos sigue una din\u00e1mica com\u00fan iniciada con la detecci\u00f3n del h\u00edbrido tumoral p210 bcr-abl, seguida de la reaparici\u00f3n de hematopoyesis procedente del receptor en la celularidad mioloide cd15+, independientemente del perfil presentado en las l\u00edneas linfoides y acompa\u00f1\u00e1ndose de positividad para el transcrito p190 bcr-abl en las semanas o meses precedentes a la detecci\u00f3n por citogen\u00e9tica del cromosoma philadelphia, que conduce finalmente a la reca\u00edda hematol\u00f3gica. La respuesta al tratamiento de la reca\u00edda tras infusi\u00f3n de linfocitos del donante sigui\u00f3 una cin\u00e9tica similar de orden inverso, mientras que el tratamiento con alfa-interfer\u00f3n no parece influir en la detecci\u00f3n de los par\u00e1metros moleculares.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor biologico y predictivo de recaida del seguimiento molecular mediante estudio del qimerismo hematopoyetico con vntr-pcr y deteccion de transcritos bcr-abl p210\/p190 en pacientes trasplantados de medula osea leucemia mieloide cronica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor biologico y predictivo de recaida del seguimiento molecular mediante estudio del qimerismo hematopoyetico con vntr-pcr y deteccion de transcritos bcr-abl p210\/p190 en pacientes trasplantados de medula osea leucemia mieloide cronica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josefina Serrano Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Torres G\u00f3mez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal:  Jimenez perez Jos\u00e9 Antonio <\/li>\n<li> Tomas Martinez Jos\u00e9 f. (vocal)<\/li>\n<li>inmaculada c. Herrera arroyo (vocal)<\/li>\n<li> D\u00edez mart\u00edn Jos\u00e9 Luis (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josefina Serrano Lopez La principal causa de fallo del trasplante en lmc es la recidiva de la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,973,218,195,139,156],"tags":[29697,50574,99024,101263,101264,101265],"class_list":["post-39251","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cordoba","category-hematologia","category-hemopatologia","category-medicina-interna","category-patologia","tag-antonio-torres-gomez","tag-diez-martin-jose-luis","tag-inmaculada-c-herrera-arroyo","tag-jimenez-perez-jose-antonio","tag-josefina-serrano-lopez","tag-tomas-Martinez-jose-f"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39251","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39251"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39251\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39251"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39251"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39251"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}