{"id":39286,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/mutaciones-en-el-complejo-genetico-de-las-apolipoproteinas-ai-ciii-aiv-que-determinan-la-aparicion-de-hipercolesterolemia-y-su-interaccion-con-la-dieta\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"mutaciones-en-el-complejo-genetico-de-las-apolipoproteinas-ai-ciii-aiv-que-determinan-la-aparicion-de-hipercolesterolemia-y-su-interaccion-con-la-dieta","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/mutaciones-en-el-complejo-genetico-de-las-apolipoproteinas-ai-ciii-aiv-que-determinan-la-aparicion-de-hipercolesterolemia-y-su-interaccion-con-la-dieta\/","title":{"rendered":"Mutaciones en el complejo genetico de las apolipoproteinas ai-ciii-aiv que determinan la aparicion de hipercolesterolemia y su interaccion con la dieta."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Francisco Jose Fuentes  Jimenez <\/strong><\/h2>\n<p>Introducci\u00f3n: la mayor\u00eda de las hiperlipemias tienen un origen polig\u00e9nico como consecuencia de la interacci\u00f3n entre m\u00faltiples variaciones gen\u00e9ticas y la dieta. A su bez, la dieta es el principal determinante ex\u00f3geno de las cifras de colesterol plasm\u00e1tico. Los locus gen\u00e9ticos m\u00e1s importantes en la regulaci\u00f3n de los niveles de colesterol, son el complejo gen\u00e9tico de las apoprote\u00ednas ai-ciii-aiv y el locus de la apo e. Hip\u00f3tesis de trabajo: nuestra hip\u00f3tesis pretende demostrar que la hipercolesterolemia polig\u00e9nica (hp) est\u00e1 influenciada por la interacci\u00f3n entre variaciones gen\u00e9ticas menores de dichos genes y la composici\u00f3n de la dieta. Objetivos: examinar si la hp es en parte debida a la interacci\u00f3n de la dieta con las variaciones gen\u00e9ticas, g\/a (-76 bp) de la regi\u00f3n promotora del gen de la apo a-i y 347ser\/thr del gen de la apo a-iv. Establecer si los genotipos definidos por las variaciones gen\u00e9ticas, g\/a (-76 bp) de la regi\u00f3n promotora del gen de la apo a-i, 347ser\/thr y 360his\/gln del gen de la apo a-iv, definen subgrupos de poblaci\u00f3n con hp tributarios de beneficiarse m\u00e1s de una dieta mediterr\u00e1nea o de una dieta rica en hidratos de carbono. Sujetos, material y m\u00e9todos: se seleccionaron 34 sujetos por tener una edad comprendida entre 18 y 65 a\u00f1os, presentar cifras de colesterol total superiores a 200 mg\/dl y menores de 350 mg\/dl y menores de 350 mg-dl, cifras de triglic\u00e9ridos menores de 200 mg\/dl, no mostrar evidencia de enfermedad cr\u00f3nica y haber descartado otras causas primarias y secundarias de hiperlipemia. Dise\u00f1o experimental: comprativo, con tres fases de dieta y dos per\u00edodos cruzados. Fueron sometidos a tres per\u00edodos de intervenci\u00f3n diet\u00e9titca isocal\u00f3ricos respecto a sus dietas habituales. En primer lugar una dieta rica en grasa saturada, seguida de una dieta rica en carbohidratos y de un dieta rica en grasa monoinsaturada. Al final de cada periodo diet\u00e9tico se determinaron<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Mutaciones en el complejo genetico de las apolipoproteinas ai-ciii-aiv que determinan la aparicion de hipercolesterolemia y su interaccion con la dieta.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Mutaciones en el complejo genetico de las apolipoproteinas ai-ciii-aiv que determinan la aparicion de hipercolesterolemia y su interaccion con la dieta. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Francisco Jose Fuentes  Jimenez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 C\u00f3rdoba<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Francisco Perez Jimenez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez <\/li>\n<li>pedro Mata lopez (vocal)<\/li>\n<li>Antonio Rodr\u00edguez franco (vocal)<\/li>\n<li>Miguel Pocovi mieras (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Francisco Jose Fuentes Jimenez Introducci\u00f3n: la mayor\u00eda de las hiperlipemias tienen un origen polig\u00e9nico como consecuencia de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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