{"id":39322,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/determinacion-de-precursores-de-la-sintesis-de-oxido-nitrico-en-la-isquemia-cerebral-aguda\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"determinacion-de-precursores-de-la-sintesis-de-oxido-nitrico-en-la-isquemia-cerebral-aguda","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/determinacion-de-precursores-de-la-sintesis-de-oxido-nitrico-en-la-isquemia-cerebral-aguda\/","title":{"rendered":"Determinacion de precursores de la sintesis de oxido nitrico en la isquemia  cerebral aguda."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Carlos Vazquez Espierrez <\/strong><\/h2>\n<p>El fallo bioenerg\u00e9tico ocasionado por la disminuci\u00f3n del flujo sangu\u00edneo cerebral ocasiona la lesi\u00f3n celular, fundamentalmente mediante dos mecanismos: el desarrollo de acidosis y la entrada de calcio i\u00f3nico en la c\u00e9lula. La estimulaci\u00f3n de los receptores nmda produce un notable aumento del calcio intracelular y de la puesta en marcha de la cascada isqu\u00e9mica dependiente del calcio que originar\u00e1 la muerte celular. Uno de los procesos calcio-dependientes es la produci\u00f3n de \u00f3xido n\u00edtrico por modificaci\u00f3n del amino\u00e1cido l-arginina. Este trabajo tiene por objeto valorar las modificaciones de l-arginina en plasma y en l\u00edquido cefalorraqu\u00eddeo y el \u00f3xido n\u00edtrico en l\u00edquido cefalorraqu\u00eddeo durante la fase aguda de la isquemia cerebral.  material y m\u00e9todos: el estudio se realiz\u00f3 sobre una muestra total de 300 personas, de las cuales 250 corresponden a pacientes con infarto cerebral hemisf\u00e9rico ingresados en las primeras 24 horas desde el inicio de la sintomatolog\u00eda y a 50 controles. En el momento del ingreso se realiz\u00f3 una tc cerebral y se obtuvo muestra de sangre y de l\u00edquido cefalorraqu\u00eddeo. la l-arginina se determin\u00f3 por hplc y el no se determin\u00f3 mediante la cuantificaci\u00f3n de nitratos y nitritos mediante un m\u00e9todo colorim\u00e9trico. Las variables estudiadas fueron: mortalidad en los 3 primeros meses, intensidad de la lesi\u00f3n neurol\u00f3gica valorada por la escala canadiense al ingreso y a los 3 meses, repercusi\u00f3n funcional del ictus valorado por el \u00edndice de barthel, progresi\u00f3n de la sintomatolog\u00eda neurol\u00f3gica en las primeras 48 horas y volumen del infarto medido en una tc realizada entre el 4. Y 7. D\u00eda despu\u00e9s del ingreso.  resultados: la concentraci\u00f3n de l-arginina en plasma y en l\u00edquido cefalorraqu\u00eddeo fue significativamente inferior en los pacientes que en los controles, aunque no se relacion\u00f3 con el volumen del infarto ni con la intensidad del d\u00e9ficit neurol\u00f3gico. La concentraci\u00f3n de no<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Determinacion de precursores de la sintesis de oxido nitrico en la isquemia  cerebral aguda.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Determinacion de precursores de la sintesis de oxido nitrico en la isquemia  cerebral aguda. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Carlos Vazquez Espierrez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Castillo S\u00e1nchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: manuel Noya  Garc\u00eda <\/li>\n<li>alfonso Castro Garc\u00eda (vocal)<\/li>\n<li>julio Fermoso garcia (vocal)<\/li>\n<li>Jos\u00e9 Luis Labandeira garcia (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Carlos Vazquez Espierrez El fallo bioenerg\u00e9tico ocasionado por la disminuci\u00f3n del flujo sangu\u00edneo cerebral ocasiona la lesi\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,139,1880,977],"tags":[35148,101390,21386,3006,47683,2879],"class_list":["post-39322","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-medicina-interna","category-neurologia","category-santiago-de-compostela","tag-alfonso-castro-garcia","tag-carlos-vazquez-espierrez","tag-jose-castillo-sanchez","tag-jose-luis-labandeira-garcia","tag-julio-fermoso-garcia","tag-manuel-noya-garcia"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39322","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39322"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39322\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39322"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39322"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39322"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}