{"id":39328,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/distribucion-celular-e-intracelular-del-receptor-de-la-hormona-liberadora-de-la-hormona-del-crecimiento\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"distribucion-celular-e-intracelular-del-receptor-de-la-hormona-liberadora-de-la-hormona-del-crecimiento","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/distribucion-celular-e-intracelular-del-receptor-de-la-hormona-liberadora-de-la-hormona-del-crecimiento\/","title":{"rendered":"Distribucion celular e intracelular del receptor de la hormona  liberadora de la hormona del crecimiento."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Pintos Martinez Elena Mercedes <\/strong><\/h2>\n<p>El estudio de los receptores celulares de p\u00e9ptidos hormonales ha ampliado el concepto cl\u00e1sico de su acci\u00f3n en la modulaci\u00f3n endocrina de la secreci\u00f3n de otros p\u00e9ptidos en las c\u00e9lulas diana, con probable implicaci\u00f3n en la regulaci\u00f3n del crecimiento celular. La demostraci\u00f3n de la s\u00edntesis de la hormona liberadora de la hormona del crecimiento (ghrh) y de su receptor (ghrh-r) en tejidos extrahipofisarios de rata, hac\u00eda necesaria una b\u00fasqueda del ghrh-r en tejidos humanos extrahipofisarios, as\u00ed como el estudio de su ubicaci\u00f3n celular, hasta el momento desconocida, ya que los trabajos previos sobre el ghrh-r realizados en ratas, estudiaban el arn mediante rt-pcr o t\u00e9cnicas de inmunoblot sobre cultivos celulares o fraccionamientos de membrana, que no permit\u00edan determinar la localizaci\u00f3n del receptor. En este trabajo se demuestra la presencia del ghrh-r en numerosas muestras histol\u00f3gicas de tejidos normales humanos y de rata, y en tejidos tumorales humanos mediante un anticuerpo policlonal dirigido contra una fracci\u00f3n proteica del segmento c-terminal intracelular del ghrh-r, utilizando el sistema del complejo estreptavidina-biotina-peroxidasa como m\u00e9todo inmunohistoqu\u00edmico de detecci\u00f3n antig\u00e9nica y una t\u00e9cnica de inmunofluorescencia de doble marcaje, y se establece su localizaci\u00f3n celular. Los hallazgos son superponibles casi en su totalidad en ambas especies, con intensa expresi\u00f3n del ghrh-r en \u00f3rganos endocrinos (c\u00e9l. Somatotropas de adenohip\u00f3fisis, tiroides, ovario&#8230;), no endocrinos (piel, m\u00fasculo, cartilago&#8230;) Y en c\u00e9lulas implicadas en intercambios i\u00f3nicos (c\u00e9l. Parietales g\u00e1stricas, c\u00e9l. De los conductos estriados de las gl\u00e1ndulas salivares y de los t\u00fabulos contorneados distales del ri\u00f1\u00f3n), con patr\u00f3n de inmunotinci\u00f3n citoplasm\u00e1tica y\/o nuclear.  asimismo, se establece la ubicaci\u00f3n intracelular del ghrh-r mediante t\u00e9cnica de inmunocitoqu\u00edmica con marcaje de los complejos receptor\/ant<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Distribucion celular e intracelular del receptor de la hormona  liberadora de la hormona del crecimiento.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Distribucion celular e intracelular del receptor de la hormona  liberadora de la hormona del crecimiento. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Pintos Martinez Elena Mercedes <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jeronimo Forteza Vila<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: andr\u00e9s Beiras iglesias <\/li>\n<li>Manuel avelino Giraldez garcia (vocal)<\/li>\n<li>josep Lloreta trull (vocal)<\/li>\n<li> Casta\u00f1o oreja Mar\u00eda  teresa (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pintos Martinez Elena Mercedes El estudio de los receptores celulares de p\u00e9ptidos hormonales ha ampliado el concepto 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