{"id":39399,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/influencia-del-bloqueo-de-la-fagocitosis-de-las-celulas-de-kupffer-la-cirrosis-hepatica-y-la-hipertension-portal-en-la-mortalidad-de-la-sepsis-de-origen-abdominal\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"influencia-del-bloqueo-de-la-fagocitosis-de-las-celulas-de-kupffer-la-cirrosis-hepatica-y-la-hipertension-portal-en-la-mortalidad-de-la-sepsis-de-origen-abdominal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/influencia-del-bloqueo-de-la-fagocitosis-de-las-celulas-de-kupffer-la-cirrosis-hepatica-y-la-hipertension-portal-en-la-mortalidad-de-la-sepsis-de-origen-abdominal\/","title":{"rendered":"Influencia del bloqueo de la fagocitosis de las celulas de kupffer, la  cirrosis hepatica y la hipertension portal en la mortalidad de la  sepsis de origen abdominal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Esteban Otero Anton <\/strong><\/h2>\n<p>Los pacientes con cirrosis hep\u00e1tica tienen una mayor preValencia y gravedad de infecciones bacterianas, a lo que pueden contribuir diversos factores presentes en la cirrosis hep\u00e1tica: alteraci\u00f3n de la fagocitosis por las c\u00e9lulas de kupffer, hipertensi portal con presencia de shunts portosist\u00e9micos u otras alteraciones asociadas a la disfunci\u00f3n hepatocelular.  el objetivo principal de esta tesis fue analizar la influencia de la hipertensi\u00f3n portal aislada, bloqueo de la fagocitosis de las c\u00e9lulas de kupffer aislado y la experimental de sepsis bacteriana de origen abdominal. para ello se desarrollaron los siguientes modelos experimentales en ratas hembras sprague-dawley: 1) cirrosis biliar secundaria (cbs) mediante ligadura y secci\u00f3n del col\u00e9doco, 2) hipertensi\u00f3n portal aislada (htp) mediante ligadura parcial de la vena porta, 3) bloqueo de la fagocitosis de las c\u00e9lulas de kupffer (bfck) mediante administraci\u00f3n intravenosa de 10 mg\/kg de peso de cloruro de gadolinio, 4) sepsis de origen abdominal mediante ligadura y punci\u00f3n del ciego (lpc) con agujas de diferentes calibres o incisi\u00f3n con bisturi, y 5) endotoxemia mediante la administraci\u00f3n intraperitoneal de endotoxina de escherichia coli. Se comprob\u00f3 el funcionamiento de dichos modelos y se compar\u00f3 la mortalidad tras lpc o tras administraci\u00f3n de endotoxina intraperitoneal en ratas control, con cbs, con htp, con bfck y sham (intervenci\u00f3n fantasma previa consistente en laparotom\u00eda y exposici\u00f3n del hilio hep\u00e1tico).  se comprob\u00f3 el desarrollo de hipertensi\u00f3n portal y shunts portosist\u00e9micos a las 8 semanas de ligar parcialmente la vena porta. A las 8 semanas de la ligadura y secci\u00f3n del col\u00e9doco se produjo disfunci\u00f3n hepatocelular, hipertensi\u00f3n portal y datos morfol\u00f3gicos de colestasis cr\u00f3nica con cirrosis biliar secundaria en desarrollo. Se comprob\u00f3 asimismo la disminuci\u00f3n de la funci\u00f3n fagoc\u00edtica hep\u00e1tica a las 24 horas de la inyecci\u00f3n intraven<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Influencia del bloqueo de la fagocitosis de las celulas de kupffer, la  cirrosis hepatica y la hipertension portal en la mortalidad de la  sepsis de origen abdominal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Influencia del bloqueo de la fagocitosis de las celulas de kupffer, la  cirrosis hepatica y la hipertension portal en la mortalidad de la  sepsis de origen abdominal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Esteban Otero Anton <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Gonzalez Quintela<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Guardia mass\u00f3 <\/li>\n<li>evaristo Varo p\u00e9rez (vocal)<\/li>\n<li>valent\u00edn Cuervas-mons mart\u00ednez (vocal)<\/li>\n<li>Santiago Tome Martinez de rituerto (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Esteban Otero Anton Los pacientes con cirrosis hep\u00e1tica tienen una mayor preValencia y gravedad de infecciones bacterianas, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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