{"id":39401,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/cambios-morfo-funcionales-inducidos-por-la-lesion-del-sistema-dopaminergico-nigroestriatal-en-modelos-experimentales-de-parkinsonismo\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"cambios-morfo-funcionales-inducidos-por-la-lesion-del-sistema-dopaminergico-nigroestriatal-en-modelos-experimentales-de-parkinsonismo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/cambios-morfo-funcionales-inducidos-por-la-lesion-del-sistema-dopaminergico-nigroestriatal-en-modelos-experimentales-de-parkinsonismo\/","title":{"rendered":"Cambios morfo-funcionales inducidos por la lesion del sistema dopaminergico  nigroestriatal en modelos experimentales de parkinsonismo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lopez Martin M. Elena <\/strong><\/h2>\n<p>Utilizando un modelo animal de hemiparkinsonismo en ratas se han descrito importantes cambios presin\u00e1pticos y postsin\u00e1pticos en el proceso de degeneraci\u00f3n de los terminales dopamin\u00e9rgicos tras la lesi\u00f3n unilateral de la v\u00eda nigroestriatal con 6-ohda. Se ha visto que estos cambios inmunohistoqu\u00edmicos y de comportamiento rotacional ocurren como consecuencia directa de la lesi\u00f3n de las terminales dopamin\u00e9rgicas aunque tambi\u00e9n hay una participaci\u00f3n de los aferentes corticoestriatales, en algunos cambios de tipo motor. En este mismo modelo se han descrito tambi\u00e9n tras la lesi\u00f3n unilateral con 6-ohda importantes cambios en distinta subunidades de los receptores gaba-a en el estriado, g. P. Y t\u00e1lamo en periodo agudo que luego son compensados en buena parte. Tras la realizaci\u00f3n de implantes ect\u00f3picos de c\u00e9lulas dopamin\u00e9rgicas embrionarias en t\u00e1lamo se ha demostrado que la inervaci\u00f3n dopamin\u00e9rgica no es necesaria para el desarrollo de receptores dopamin\u00e9rgicos, si bien estos son hipersensibles. se ha desarrollado un nuevo test de comportamiento animal en el tapiz rodante para evaluar parkinsonismos bilaterales usando ratones lesionados con mptp. Se ha demostrado que los trasplantes de c\u00e9lulas dopamin\u00e9rgicas son funcionales en si mismos y no es necesario el sistema dopamin\u00e9rgico del hu\u00e9sped para la recuperaci\u00f3n de los par\u00e1metros estudiados. Se ha descrito la acci\u00f3n tr\u00f3pica o de gu\u00eda, del factor neurotr\u00f3fico de la gl\u00eda (gdnf) para la inervaci\u00f3n del estriado por las fibras dopamin\u00e9rgicas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Cambios morfo-funcionales inducidos por la lesion del sistema dopaminergico  nigroestriatal en modelos experimentales de parkinsonismo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Cambios morfo-funcionales inducidos por la lesion del sistema dopaminergico  nigroestriatal en modelos experimentales de parkinsonismo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lopez Martin M. Elena <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Labandeira Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Carlos Dieguez gonzalez <\/li>\n<li>Jos\u00e9 angel Armengol butron de mujica (vocal)<\/li>\n<li>Francisco Mora teruel (vocal)<\/li>\n<li>Manuel Arias gomez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lopez Martin M. Elena Utilizando un modelo animal de hemiparkinsonismo en ratas se han descrito importantes cambios [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[212,35,9,139,8868,1880,965,156,1323,977],"tags":[15487,4278,10804,3006,101531,101532],"class_list":["post-39401","post","type-post","status-publish","format-standard","hentry","category-biologia-humana","category-ciencias-de-la-vida","category-ciencias-medicas","category-medicina-interna","category-neuroanatomia-humana","category-neurologia","category-neuropatologia","category-patologia","category-patologia-experimental","category-santiago-de-compostela","tag-carlos-dieguez-gonzalez","tag-francisco-mora-teruel","tag-jose-angel-armengol-butron-de-mujica","tag-jose-luis-labandeira-garcia","tag-lopez-martin-m-elena","tag-manuel-arias-gomez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39401","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39401"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39401\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39401"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39401"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39401"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}