{"id":39415,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/marcadores-bioquimicos-de-dano-neuronal-a-nivel-del-liquido-cefalorraquideo-en-las-meningitis-convulsiones-febriles-y-sepsis-en-la-edad-pediatrica\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"marcadores-bioquimicos-de-dano-neuronal-a-nivel-del-liquido-cefalorraquideo-en-las-meningitis-convulsiones-febriles-y-sepsis-en-la-edad-pediatrica","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/marcadores-bioquimicos-de-dano-neuronal-a-nivel-del-liquido-cefalorraquideo-en-las-meningitis-convulsiones-febriles-y-sepsis-en-la-edad-pediatrica\/","title":{"rendered":"Marcadores bioquimicos de da\u00f1o neuronal a nivel del liquido cefalorraquideo  en las meningitis, convulsiones febriles y sepsis en la edad pediatrica."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Elena Cid Fernandez <\/strong><\/h2>\n<p>Introducci\u00f3n y objetivos: las meningitis, convulsiones y sepsis son procesos patol\u00f3gicos frecuentes en la infancia cuya fisiopatolog\u00eda no se conoce por completo, sobre todo a nivel celular y bioqu\u00edmico. En condiciones de hipoxia se pueden producir alteraciones del metabolismo energ\u00e9tico y de la estructura celular, con degradaci\u00f3n del atp y liberaci\u00f3n de enzimas celulares respectivamente. El presente estudio ha intentado confirmar los valores de referencia en el lcr de los metabolitos pur\u00ednicos, determinar los valores de referencia de la enolasa espec\u00edfica neuronal en dicho fluido y valorar las concentraciones de dichos marcadores bioqu\u00edmicos en ni\u00f1os con meningitis, convulsiones febriles y sepsis.  material y m\u00e9todos: hemos estudiado 382 ni\u00f1os distribuidos en cuatro grupos (160 controles, 100 meningitis, 90 convulsiones febriles y 32 sepsis sin meningitis). En todos se determin\u00f3 en una muestra de lcr la concentraci\u00f3n de amp, imp, adenosina, inosina, guanosina, adenina, guanina, hipoxantina, xantina y \u00e1cido \u00farico, mediante la t\u00e9cnica de cromatografia l\u00edquida de alta resoluci\u00f3n, as\u00ed como la enolasa espec\u00edfica neuronal mediante enzimo-inmunoan\u00e1lisis.  resultados: los valores de referencia (micromo\/l de los metabolitos pur\u00ednicos son: amp: 1.80, imp: 3.19, inosina: 0.64, adenosina: 0.90, guanosina: 0.16, adenina: 0.37, guanina: 0.58, hipoxantina: 3.40, xantina: 2.32, acido \u00farico: 10.40 y de la enolasa espec\u00edfica neuronal (ng\/ml): 1.52. En las meningitis bacterianas se observ\u00f3 un incremento significativa de la hipoxantina, xantina y \u00e1cido \u00farico respecto al grupo control. en las meningitis v\u00edricas se encontr\u00f3 un incremento significativo de inosina, guanosina, xantina, \u00e1cido \u00farico y enolasa respecto a los controles. En las meningitis tuberculosas demostramos un aumento significativo de inosina, xantina y \u00e1cido \u00farico. En las convulsiones febriles simples no se evidenciaron alteraciones de los metab<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Marcadores bioquimicos de da\u00f1o neuronal a nivel del liquido cefalorraquideo  en las meningitis, convulsiones febriles y sepsis en la edad pediatrica.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Marcadores bioquimicos de da\u00f1o neuronal a nivel del liquido cefalorraquideo  en las meningitis, convulsiones febriles y sepsis en la edad pediatrica. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Elena Cid Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Santiago de compostela<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Castro Gago<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Tojo sierra <\/li>\n<li>Rafael Palencia luaces (vocal)<\/li>\n<li>Santiago Rodr\u00edguez-segade villamar\u00edn (vocal)<\/li>\n<li>Jaime Campos castello (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Elena Cid Fernandez Introducci\u00f3n y objetivos: las meningitis, convulsiones y sepsis son procesos patol\u00f3gicos frecuentes en la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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