{"id":39467,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/virus-de-epstein-barr-y-cancer-oral-aportaciones-etiopatogenicas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"virus-de-epstein-barr-y-cancer-oral-aportaciones-etiopatogenicas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/virus-de-epstein-barr-y-cancer-oral-aportaciones-etiopatogenicas\/","title":{"rendered":"Virus de epstein-barr y cancer oral. aportaciones etiopatogenicas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Rodriguez Fernandez Manuel Jes\u00fas <\/strong><\/h2>\n<p>Introduccion  el virus de epstein-barr (veb) est\u00e1 consistentemente asociado a procesos oncog\u00e9nicos en dos casos: linfoma de burkitt y carcinoma nasofar\u00edngeo. En estos tumores el virus expresa varias prote\u00ednas del ciclo latente, cuyo patr\u00f3n de expresi\u00f3n var\u00eda en funci\u00f3n del tipo celular. Muchas de estas prote\u00ednas tienen car\u00e1cter oncog\u00e9nico, siendo una de sus principales oncoprote\u00ednas la prote\u00edna latente de membrana lmp-1. Se ha analizado la presencia e implicaci\u00f3n del veb y de su principal oncoprote\u00edna lmp-1 en el carcinoma m\u00e1s frecuente de cavidad oral: el carcinoma epidermoide, con el prop\u00f3sito de conocer el estado latente o proliferativo que desarrolla el virus en estos tumores y determinar la posible influencia del veb sobre la supervivencia.  material y metodo  se estudiaron 78 enfermos de carcinoma epidermoide de cavidad oral (ceco), de los cuales se recogieron los datos completos de su historial cl\u00ednico y de las caracter\u00edsticas histol\u00f3gicas del tumor. se utilizaron bloques de parafina de los tumores primarios a partir de los cuales se estudi\u00f3: la presencia del genoma del veb mediante la reacci\u00f3n en cadena de la polimerasa, la expresi\u00f3n del arn no poliadenilado del veb (eber) mediante hibridaci\u00f3n in situ, y expresi\u00f3n de la prote\u00edna lmp-1 mediante t\u00e9cnica inmunohistoqu\u00edmica de fosfatasa.  resultados  se encontr\u00f3 un 19.2% de tumores positivos para la presencia del genoma del veb. En 50 muestras de mucosa gingival de pacientes sanos utilizados como control se encontr\u00f3 un 0% de positividad en esta prueba. En ninguna muestra de este estudio se observ\u00f3 positividad para el arn eber mediante hibridaci\u00f3n in situ. El 85.7% de los tumores positivos para el veb expresaron lmp-1 en c\u00e9lulas neopl\u00e1sicas. Asimismo, en 11 casos se expres\u00f3 lmp-1 en los linfocitos infiltrantes del tumor. adem\u00e1s, en 3 casos se observaron c\u00e9lulas neopl\u00e1sicas positivas penetrando en espacios vasculares. en todos lo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Virus de epstein-barr y cancer oral. aportaciones etiopatogenicas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Virus de epstein-barr y cancer oral. aportaciones etiopatogenicas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Rodriguez Fernandez Manuel Jes\u00fas <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Granada<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Gutierrez Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Ana Mar\u00eda Castillo perez <\/li>\n<li>Mar\u00eda Jos\u00e9 Linares sicilia (vocal)<\/li>\n<li>Francisco Esteban ortega (vocal)<\/li>\n<li>encarnaci\u00f3n Clavijo frutos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rodriguez Fernandez Manuel Jes\u00fas Introduccion el virus de epstein-barr (veb) est\u00e1 consistentemente asociado a procesos oncog\u00e9nicos en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,141,140],"tags":[81891,24861,20928,6963,22023,101631],"class_list":["post-39467","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-cirugia","category-estomatologia-y-ortodoncia","tag-ana-maria-castillo-perez","tag-encarnacion-clavijo-frutos","tag-francisco-esteban-ortega","tag-jose-gutierrez-fernandez","tag-maria-jose-linares-sicilia","tag-rodriguez-fernandez-manuel-jesus"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39467","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39467"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39467\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39467"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}