{"id":39600,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-molecular-y-evolutivo-del-gen-bf-fragmento-ba-del-complemento-en-primates\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-molecular-y-evolutivo-del-gen-bf-fragmento-ba-del-complemento-en-primates","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-molecular-y-evolutivo-del-gen-bf-fragmento-ba-del-complemento-en-primates\/","title":{"rendered":"Estudio molecular y evolutivo del gen bf (fragmento ba) del complemento en primates."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Miguel Angel Moreno Pelayo <\/strong><\/h2>\n<p>El gen bf del complemento mapea en la regi\u00f3n de clase iii del sistema principal de histocompatibilidad en humanos. La prote\u00edna bf presenta tres regiones: la regi\u00f3n ba, formada por 3 dominios del tipo \u00abshort consensus repeats\u00bb, una regi\u00f3n similar al dominio de tipo a del factor von-willebrad, y una tercera regi\u00f3n \u00abser\u00edn-proteasa\u00bb. Bf activa la cascada del complemento por la v\u00eda alternativa. El estudio de esta prote\u00edna reviste gran importancia, puesto que, al no existir individuos con enfermedades causadas por d\u00e9ficit de bf, es posible que la ausencia de dicho componente tenga un efecto absolutamente delet\u00e9reo. Esto apoyar\u00eda que bf interviene de manera fundamental en la respuesta inmune.  los objetivos de este trabajo han sido la secuenciaci\u00f3n del cdna y del dna que codifica para ba en varias especies de primates, hasta una edad de divergencia respecto a la especie humana de unos 30 millones de a\u00f1os.  los resultados obtenidos comprenden 15 secuencias de ba de diferentes especies. Adem\u00e1s se ha obtenido una nueva variante humana. Existen dos zonas de variabilidad en ba, una en la parte inicial del exon 2 y otra en la parte final del mismo. no obstante existe una gran conservaci\u00f3n en la secuencia proteica de ba entre estas especies. Se han observado, incluso, variantes id\u00e9nticas en una secuencia proteica deducida entre hombre y gorila. Esto sugiere la presencia de fuerzas selectivas para mantener la proteina durante al menos 9 millones de a\u00f1os.  as\u00ed mismo, de las 3 regiones de ba propuestas para la uni\u00f3n con c3b, las 2 y 3 est\u00e1n muy conservadas pero la primera presenta gran variabilidad, por lo que parece tener menos importancia en dicha funci\u00f3n. los residuos encargados de mantener la estructura de los dominios scr est\u00e1n muy conservados.  por \u00faltimo, el an\u00e1lisis evolutivo demuestra que este gen, de bajo polimorfismo, evoluciona de forma \u00abintra-espec\u00edfica\u00bb a diferencia de otros genes pr\u00f3ximos (mi<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio molecular y evolutivo del gen bf (fragmento ba) del complemento en primates.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio molecular y evolutivo del gen bf (fragmento ba) del complemento en primates. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Miguel Angel Moreno Pelayo <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Antonio Arnaiz Villena<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: eduardo Martinez naves <\/li>\n<li>felix Garcia sanchez (vocal)<\/li>\n<li>Mar\u00eda  Luisa Toribio garcia (vocal)<\/li>\n<li>Santiago Rodriguez de cordoba (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Miguel Angel Moreno Pelayo El gen bf del complemento mapea en la regi\u00f3n de clase iii del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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