{"id":39661,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":""},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"modificaciones-in-vivo-en-la-composicion-lipidica-estructura-y-funcion-de-la-membrana-plasmatica-de-plaqueta-humana-de-sujetos-hiperlipidemicos-el-entorno-lipidico-del-receptor-del-fibrinogeno-inte","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/modificaciones-in-vivo-en-la-composicion-lipidica-estructura-y-funcion-de-la-membrana-plasmatica-de-plaqueta-humana-de-sujetos-hiperlipidemicos-el-entorno-lipidico-del-receptor-del-fibrinogeno-inte\/","title":{"rendered":"Modificaciones in vivo en la composicion lipidica, estructura y funcion de la membrana plasmatica de plaqueta humana de sujetos hiperlipidemicos: el entorno lipidico del receptor del fibrinogeno (integrina alfaiib-beta3)."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Rafael Garcia Guerra <\/strong><\/h2>\n<p>Aunque es bien conocido que las modificaciones in vivo de la composici\u00f3n lip\u00eddica del plasma sangu\u00edneo alteran la composici\u00f3n de la plaqueta circulante, no est\u00e1 bien definido la extensi\u00f3n ni las consecuencias estructurales, din\u00e1mico moleculares y funcionales de estas alteraciones en la membrana plasm\u00e1tica de la plaqueta humana (mpph) y, por tanto, su contribuci\u00f3n a la patog\u00e9nesis de la ateroesclerosis, de la trombosis arterial aguda y de la hiperplasia neointimal. A este respecto, cabe esperar que la estructura, la din\u00e1mica molecular y la funci\u00f3n de los receptores de mpph este modulada por la composici\u00f3n de la bicapa lip\u00eddica. en la presente tesis se estudi\u00f3 la correlaci\u00f3n existente entre alteraciones in vivo de la composici\u00f3n lip\u00eddica del plasma y las modificaciones de la composici\u00f3n lip\u00eddica, orden estructural de la bicapa y la funci\u00f3n de mpph de sujetos con hiperlipidemias. adem\u00e1s se inici\u00f3 la caracterizaci\u00f3n del entorno lip\u00eddico de alfa  beta3 o gpiib\/iiia, ya que su condici\u00f3n de prote\u00edna integral mayoritaria de mpph le hacen unos de los mejores objetivos individualizados para seguir las modificaciones causadas por la alteraci\u00f3n de la composici\u00f3n lip\u00eddica. Tras determinarse la composici\u00f3n lip\u00eddica y el orden estructural de mpph en un grupo de individuos sanos, se estableci\u00f3 que el contenido de gpiib\/iiia es una referencia fiable para expresar el contenido de l\u00edpidos de mpph. as\u00ed se pudo observar un aumento del contenido absoluto de colesterol (cl) y de fosfol\u00edpidos (pl) en mpph de sujetos con hiperlipidemia, siendo este aumento diferente seg\u00fan el tipo de hiperlipidemia. As\u00ed, se observ\u00f3 que con respecto al grupo control, la relaci\u00f3n molar cl\/pl aumenta en las hipercolesterolemias (0.70), disminuye en las hipertrigliceridemias (0.62) y no se modifica en las hipercolesterolemias combinadas con hipertrigliceridemia (0.65). Tambi\u00e9n se observ\u00f3 que el contenido de cl y de pl en<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Modificaciones in vivo en la composicion lipidica, estructura y funcion de la membrana plasmatica de plaqueta humana de sujetos hiperlipidemicos: el entorno lipidico del receptor del fibrinogeno (integrina alfaiib-beta3).<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Modificaciones in vivo en la composicion lipidica, estructura y funcion de la membrana plasmatica de plaqueta humana de sujetos hiperlipidemicos: el entorno lipidico del receptor del fibrinogeno (integrina alfaiib-beta3). <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Rafael Garcia Guerra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jose Gonzalez Rodriguez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jos\u00e9 gregorio Gavilanes franco <\/li>\n<li>Jos\u00e9 Manuel Gonzalez ros (vocal)<\/li>\n<li>Carlos Guti\u00e9rrez merino (vocal)<\/li>\n<li>valentina Ruiz guti\u00e9rrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Rafael Garcia Guerra Aunque es bien conocido que las modificaciones in vivo de la composici\u00f3n lip\u00eddica del [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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