{"id":39774,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/investigacion-de-residuos-de-tetraciclinas-en-corderos-y-estudio-farmaceutico-de-oxitetraciclina\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"investigacion-de-residuos-de-tetraciclinas-en-corderos-y-estudio-farmaceutico-de-oxitetraciclina","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/investigacion-de-residuos-de-tetraciclinas-en-corderos-y-estudio-farmaceutico-de-oxitetraciclina\/","title":{"rendered":"Investigacion de residuos de tetraciclinas en corderos y estudio farmaceutico de oxitetraciclina."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Margarita Lobo Alonso <\/strong><\/h2>\n<p>Se han llevado a cabo dos estudios complementarios entre si en corderos: 1) investigaci\u00f3n de residuos de tetraciclinas, y 2) estudio farmacocin\u00e9tico de oxitetraciclina.  con respecto al estudio farmacocin\u00e9tico de oxitetraciclina (otc), se realiz\u00f3 en ensayo cruzado en un total de 6 corderos de raza churra de un mes de edad a dosis \u00fanica de 10 mg de otc\/kg, por vias iv, im, y oral. Las curvas plasm\u00e1ticas de otc vs tiempo se ajustaron adecuadamente a un modelo bicompartimental para su an\u00e1lisis cin\u00e9tico. Tras administraci\u00f3n iv, la t1\/2beta fu\u00e9 de 5,72 h; la t1\/2beta, fu\u00e9 v\u00eda-dependiente, prolong\u00e1ndose a valores de 8,05 y 11,28 h tras via im y oral, respectivamente. La otc present\u00f3 una alta distribuci\u00f3n tisular, siendo los valores de vss de 1,75 l\/kg. La otc se absorbi\u00f3 ampliamente y r\u00e1pidamente tras administraci\u00f3n im y oral, siendo la t1\/2a de 0,16 y 0.82 h, respectivamente. La cmax fu\u00e9 de 2,54 y 1,017  g\/ml tras administraci\u00f3n im y oral, respectivamente; estas cmax se alcanzaron a los tiempos de 0,60 y 2,48 h, respectivamente. La biodisponibilidad de la otc tras via im y oral fu\u00e9 de 52,17 y 38,7%, respectivamente. Tomando colectivamente los resultados obtenidos se puede indicar que una dosis de 10 mg\/kg durante 3 d\u00edas consecutivos por v\u00eda im y oral pudiera recomendarse para el tratamiento de microordanismos pat\u00f3genos susceptibles a otc implicados en infecciones comunes de corderos.  con respecto al estudio de residuos de tetraciclinas, se ha evaluado la presencia de las tetraciclinas, tetraciclina (tc), oxitetraciclina (otc) y clortetraciclina (ctc) y sus 4-ep\u00edmeros correspondientes en los tejidos diana h\u00edgado, ri\u00f1\u00f3n y m\u00fasculo procedentes de 133 corderos de raza churra de 1-2 meses de edad sacrificados en los mataderos de aranda de duero (burgos), pr\u00e1dena (segovia), y pedraza (segovia). Se han evaluado un total de 399 muestras tisulares. El an\u00e1lisis de residuos de tc, otc, ctc y sus 4-ep\u00edme<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Investigacion de residuos de tetraciclinas en corderos y estudio farmaceutico de oxitetraciclina.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Investigacion de residuos de tetraciclinas en corderos y estudio farmaceutico de oxitetraciclina. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Margarita Lobo Alonso <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Arturo Ramon Anadon Navarro<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: benito Del castillo garcia <\/li>\n<li>Ana Camean fernandez (vocal)<\/li>\n<li>arturo Hardisson de la torre (vocal)<\/li>\n<li>Jos\u00e9 Bello gutierrez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Margarita Lobo Alonso Se han llevado a cabo dos estudios complementarios entre si en corderos: 1) investigaci\u00f3n [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,6530,401],"tags":[67975,10092,7412,4776,18236,102108],"class_list":["post-39774","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacologia-experimental","category-toxicologia","tag-ana-camean-fernandez","tag-arturo-hardisson-de-la-torre","tag-arturo-ramon-anadon-navarro","tag-benito-del-castillo-garcia","tag-jose-bello-gutierrez","tag-margarita-lobo-alonso"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39774"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39774\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39774"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39774"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}