{"id":39821,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-efecto-de-dobesilato-de-calcio-un-derivado-ciclohexadienolico-sobre-aorta-de-conejo\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-del-efecto-de-dobesilato-de-calcio-un-derivado-ciclohexadienolico-sobre-aorta-de-conejo","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-efecto-de-dobesilato-de-calcio-un-derivado-ciclohexadienolico-sobre-aorta-de-conejo\/","title":{"rendered":"Estudio del efecto de dobesilato de calcio, un derivado ciclohexadienolico sobre aorta de conejo."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Lorente Ramos Rosa M. <\/strong><\/h2>\n<p>El dosebilato de calcio es un f\u00e1rmaco cuyo mecanismo de acci\u00f3n se conoce s\u00f3lo parcialmente. El objetivo de esta tesis fue profundizar en el mecanismo de acci\u00f3n de este compuesto mediante un estudio en arteria aorta de conejo.  se realizaron estudios en conejos control demostrando que el dobesilato de calcio produce un efecto relajante sobre arterias sometidas a tensi\u00f3n basal y contra\u00eddas con diferentes agonistas (noradrenalina y cloruro pot\u00e1sico). El f\u00e1rmaco potencia la relajaci\u00f3n endotelio dependiente producida por acetilcolina y esto se produce mediante un aumento en la s\u00edntesis\/liberaci\u00f3n de \u00f3xido n\u00edtrico, una disminuci\u00f3n de su destrucci\u00f3n por radicales libres y un aumento en la s\u00edntesis \/ liberaci\u00f3n de factor hiperpolarizante derivado del endotelio (edhf).  posteriormente se realiz\u00f3 un estudio cr\u00f3nico en conejos tratados con una sobredosis de vitamina d2 que lesiona el endotelio, y con el f\u00e1rmaco.  el dobesilato de calcio presenta un efecto de protecci\u00f3n frente a la lesi\u00f3n endotelial en este modelo. Tambi\u00e9n produce una disminuci\u00f3n en la concentraci\u00f3n inducida por noradrenalina, probablemente mediante una disminuci\u00f3n en la s\u00edntesis \/ liberaci\u00f3n de \u00f3xido n\u00edtrico (no).<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del efecto de dobesilato de calcio, un derivado ciclohexadienolico sobre aorta de conejo.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del efecto de dobesilato de calcio, un derivado ciclohexadienolico sobre aorta de conejo. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Lorente Ramos Rosa M. <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Mar\u00eda   Teresa Tejerina Sanchez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: pedro Lorenzo fernandez <\/li>\n<li>Carlos S\u00e1nchez ferrer (vocal)<\/li>\n<li>elisabet Vila calsina (vocal)<\/li>\n<li>mercedes Salaices s\u00e1nchez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Lorente Ramos Rosa M. El dosebilato de calcio es un f\u00e1rmaco cuyo mecanismo de acci\u00f3n se conoce [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,957,6530],"tags":[102204,14296,102203,7195,5260,898],"class_list":["post-39821","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacologia","category-farmacologia-experimental","tag-carlos-sanchez-ferrer","tag-elisabet-vila-calsina","tag-lorente-ramos-rosa-m","tag-maria-teresa-tejerina-sanchez","tag-mercedes-salaices-sanchez","tag-pedro-lorenzo-fernandez"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39821","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39821"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39821\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39821"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39821"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39821"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}