{"id":39838,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-accion-de-diferentes-inmunosupresores-azatioprina-ciclosporina-y-prednisona-sobre-el-eje-adreno-gonadal-y-funcionalidad-hepatica-y-renal-en-conejos-nzw\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-la-accion-de-diferentes-inmunosupresores-azatioprina-ciclosporina-y-prednisona-sobre-el-eje-adreno-gonadal-y-funcionalidad-hepatica-y-renal-en-conejos-nzw","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-de-la-vida\/estudio-de-la-accion-de-diferentes-inmunosupresores-azatioprina-ciclosporina-y-prednisona-sobre-el-eje-adreno-gonadal-y-funcionalidad-hepatica-y-renal-en-conejos-nzw\/","title":{"rendered":"Estudio de la accion de diferentes inmunosupresores (azatioprina, ciclosporina y prednisona) sobre el eje adreno-gonadal y funcionalidad hepatica y renal en conejos nzw."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pilar Millan Pastor <\/strong><\/h2>\n<p>Para estudiar las relaciones sistema inmune, eje adreno-gonadal y funcionalidad org\u00e1nica, se administraron 3 f\u00e1rmacos inmunosupresores a 40 conejos nzw. Los par\u00e1metros s\u00e9ricos estudiados fueron: igg (eia sandwich); corticosterona, androstenodiona, testosterona y estradiol (eia competici\u00f3n); bioqu\u00edmicos (hitachi 747). Los tres f\u00e1rmacos produjeron inmunosupresi\u00f3n al disminuir las iggs. Ciclosporina y azatioprina estimularon la funci\u00f3n adrenal al provocar hiperadrenocorticismo, mientras que la prednisona produjo hipoadrenocorticismo. estas alteraciones pueden ser directas o mediadas por las interleucinas del sistema inmune (il-6 e il-1). La funci\u00f3n gonadal fue inhibida por la ciclosporina, por un efecto de retrofuncionalidad negativa de androstenodiona y corticosterona sobre el hipot\u00e1lamo. La prednisona alter\u00f3 significativamente la funcionalidad hep\u00e1tica (asat, alat, prote\u00ednas t, colesterol y triglic\u00e9ridos) y renal (urea y creatinina). como conclusiones se indican que, el conejo nzw sirve como biomodelo para estudios de la accibon de inmunosupresores sobre las funciones org\u00e1nicas. La azatioprina provoc\u00f3 la menor disfunci\u00f3n, sin embargo, los 3 f\u00e1rmacos inmunosupresores ejercen un efectoen la secreci\u00f3n adrenal y\/o gonadal, poniendo de manifiesto la intercomunicaci\u00f3n entre sistema inmune-sistema endocrino.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la accion de diferentes inmunosupresores (azatioprina, ciclosporina y prednisona) sobre el eje adreno-gonadal y funcionalidad hepatica y renal en conejos nzw.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la accion de diferentes inmunosupresores (azatioprina, ciclosporina y prednisona) sobre el eje adreno-gonadal y funcionalidad hepatica y renal en conejos nzw. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pilar Millan Pastor <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Juan  Carlos Illera Del Portal<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: dieter Brandau ballnet <\/li>\n<li>inmaculada Diez prieto (vocal)<\/li>\n<li>Carlos c\u00e9sar P\u00e9rez Garc\u00eda (vocal)<\/li>\n<li> Illera del portal josefina Mar\u00eda (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pilar Millan Pastor Para estudiar las relaciones sistema inmune, eje adreno-gonadal y funcionalidad org\u00e1nica, se administraron 3 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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