{"id":39872,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/valor-pronostico-de-la-ploidia-del-dna-y-la-expresion-inmunohistoquimica-de-p53-y-p21-waf1-cip1-en-el-cancer-colorrectal\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"valor-pronostico-de-la-ploidia-del-dna-y-la-expresion-inmunohistoquimica-de-p53-y-p21-waf1-cip1-en-el-cancer-colorrectal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/valor-pronostico-de-la-ploidia-del-dna-y-la-expresion-inmunohistoquimica-de-p53-y-p21-waf1-cip1-en-el-cancer-colorrectal\/","title":{"rendered":"Valor pronostico de la ploidia del dna y la expresion inmunohistoquimica de p53 y p21 waf1\/cip1 en el cancer colorrectal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Mar\u00eda no Alcantara  Torres <\/strong><\/h2>\n<p>Objetivo.- Determinar si la ploid\u00eda del dna del tumor y el nivel de expresi\u00f3n tumoral de p53 y p21 permite discriminar los pacientes con ccr en estadio b y c de dukes con buen y mal pron\u00f3stico.  material y m\u00e9todos.- Se incluyeron en el estudio 145 pacientes con ccr en estadios a-c de dukes intervenidos de forma radical y seguidos de forma prospectiva. En an\u00e1lisis del dna se realiz\u00f3 con material fijado en parafina mediante citometr\u00eda de flujo. El nivel de expresi\u00f3n de p53 y p21 se determin\u00f3 mediante anticuerpos monoclonales espec\u00edficos utilizando material fijado en parafina y un m\u00e9todo de recuperaci\u00f3n de ant\u00edgenos. el seguimiento medio de los enfermos no fallecidos del tumor fue de 55.9+7.9 meses.  resultados.- De los 145 pacientes con ccr incluidos en el estudio, el 56% ten\u00edan dna no diploide, el 55% un nivel de expresi\u00f3n de p21 inferior al 3% de las c\u00e9lulas tumorales. el 38% de los pacientes presentaron recurrencia tumoral y el 35% del total fallecieron de la misma. La supervivencia libre de enfermedad (sle) y la supervivencia general (sg) actuarial a los 5 a\u00f1os de la cirug\u00eda fue del 61% y 63% respectivamente. En el an\u00e1lisis univariante ambos tipos de supervivencia se asociaban de forma significativa con la edad menor de 69 a\u00f1os, estadio no avanzado de dukes, mayor grado de diferenciaci\u00f3n del tumor, dna diploide y alta expresi\u00f3n de p21. en el an\u00e1lisis multivariante, para la sle ten\u00edan valor pron\u00f3stico independiente: el estadio, el grado de diferenciaci\u00f3n del tumor y la ploid\u00eda del dna; y se acercaba a la significaci\u00f3n el nivel de expresi\u00f3n de p21 (p=0.06). Para la sg ten\u00edan valor pron\u00f3stico independiente la edad, el estadio, el grado de diferenciaci\u00f3n del tumor y la ploid\u00eda del dna; el nivel de expresi\u00f3n de p21 se acercaba a ello (p=0.12). Los pacientes con tumores en estadio c de dukes y dna no diploide ten\u00edan una sle 2.6 veces mayor y una sg 2.2 veces mayor que los pacientes con tum<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Valor pronostico de la ploidia del dna y la expresion inmunohistoquimica de p53 y p21 waf1\/cip1 en el cancer colorrectal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Valor pronostico de la ploidia del dna y la expresion inmunohistoquimica de p53 y p21 waf1\/cip1 en el cancer colorrectal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Mar\u00eda no Alcantara  Torres <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Solis  Herruzo<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Enr\u00edquez de salamanca <\/li>\n<li> Pajares Garc\u00eda Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Francisco Arnalica fernandez (vocal)<\/li>\n<li>Luis Fernando Carballo alvarez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Mar\u00eda no Alcantara Torres Objetivo.- Determinar si la ploid\u00eda del dna del tumor y el nivel de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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