{"id":39918,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-del-gen-supresor-tumoral-p53-y-del-oncogen-her-2-neu-como-factores-pronostico-en-el-adenocarcinoma-de-endometrio\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-del-gen-supresor-tumoral-p53-y-del-oncogen-her-2-neu-como-factores-pronostico-en-el-adenocarcinoma-de-endometrio","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-del-gen-supresor-tumoral-p53-y-del-oncogen-her-2-neu-como-factores-pronostico-en-el-adenocarcinoma-de-endometrio\/","title":{"rendered":"Estudio del gen supresor tumoral p53 y del oncogen her-2\/neu como factores pronostico en el adenocarcinoma de endometrio."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Pluvio Jes\u00fas Coronado Martin <\/strong><\/h2>\n<p>Objetivo: estudio de la expresi\u00f3n de los genes p53 y her-2\/neu (p185) en el endometrio mediante dos t\u00e9cnicas (inmunohistoqu\u00edmica y t\u00e9cnicas cuantificadas) y determinar la relaci\u00f3n entre \u00e9sta con los factores pron\u00f3sticos cl\u00e1sicos del adenocarcinoma endometrial y la supervivencia.  material y m\u00e9todos: se estudian 161 pacientes: 94 diagnosticadas de adenocarcinoma endometrial, 34 de hiperplasia y 33 endometrios normales. En los adenocarcinomas se realiz\u00f3 una cirug\u00eda de estadificaci\u00f3n y se clasificaron los casos seg\u00fan los criterios de la figo. Se evaluaron durante el seguimiento los eventos recidiva tumoral y muerte. Se realiz\u00f3 el estudio de los genes p53 y her-2\/neu mediante t\u00e9cnicas inmunohistoqu\u00edmicas en muestras en parafina y mediante t\u00e9cnicas cuantificadas en congelaci\u00f3n (inmunolomuniscencia -lia- y enzimoinmunoan\u00e1lisis -elisa-). Se evalu\u00f3 la correlaci\u00f3n entre ambas t\u00e9cnicas seg\u00fan el \u00edndice kappa, se calcularon las curvas de kapplan-meiery los riesgos relativos para los eventos recidiva y muerte seg\u00fan el modelo de los riesgos proporcionales de cox. Para el estudio cuantificado se calcul\u00f3 el valor de m\u00e1xima sensibilidad y especificidad en la comparaci\u00f3n entre endometrios malignos y benignos mediante curvas roc.  resultados: la alta expresi\u00f3n de los genes p53 y her-2\/neu se observ\u00f3 en los adenocarcinomas de endometrioy no en las hiperplasias y endometrios normales, apareciendo en los primeros en el 13.8% para el gen p53 y en el 18.1% para el her-2\/neu. La concentraci\u00f3n de p53 en citosol fue &gt;0.8ng\/mg en el 25.3% de los adenocarcinomas y la de p185 fue &gt;48 hnu\/mg en el 72.4%. No se encontr\u00f3 correlaci\u00f3n entre la t\u00e9cnica inmunohistoqu\u00edmica y la t\u00e9cnica cuantificada, para ningunode los genes del estudio (kappa &gt;0.6). La alta expresi\u00f3n mediante inmunohistoqu\u00edmica tanto del gen p53 como del gen her-2\/neu se evidenci\u00f3 con m\u00e1s frecuencia en los carcinomas de peor pron\u00f3stico, sobre todo<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio del gen supresor tumoral p53 y del oncogen her-2\/neu como factores pronostico en el adenocarcinoma de endometrio.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio del gen supresor tumoral p53 y del oncogen her-2\/neu como factores pronostico en el adenocarcinoma de endometrio. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Pluvio Jes\u00fas Coronado Martin <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Escudero Fernandez<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Esquinos perez <\/li>\n<li> Usandizaga beguiristain Jos\u00e9 Antonio (vocal)<\/li>\n<li> Jimeno garcia Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Fernando Bonilla musoles (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Pluvio Jes\u00fas Coronado Martin Objetivo: estudio de la expresi\u00f3n de los genes p53 y her-2\/neu (p185) en [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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