{"id":39920,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/autoanticuerpos-frente-al-plexo-de-auerbach-y-hla-de-clase-ii-su-papel-en-la-acalasia\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"autoanticuerpos-frente-al-plexo-de-auerbach-y-hla-de-clase-ii-su-papel-en-la-acalasia","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/autoanticuerpos-frente-al-plexo-de-auerbach-y-hla-de-clase-ii-su-papel-en-la-acalasia\/","title":{"rendered":"Autoanticuerpos frente al plexo de auerbach y hla de clase ii: su papel en la acalasia."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Juan  Luis Mendoza  Hern\u00e1ndez <\/strong><\/h2>\n<p>La acalasia es una enfermedad neuromuscular cr\u00f3nica que afecta al es\u00f3fago. Actualmente la base etiopatog\u00e9nica de esta enfermedad es desconocida, se han propuesto diferentes teor\u00edas; 1) gen\u00e9tica, mediado por un mecanismo autos\u00f3mico recesivo, 2) infecciosa secundaria fundamentalmente a procesos virales, 3) degenerativa, consecuencia de una enfermedad neurodegenerativa tanto a nivel del sistema nervioso central como perif\u00e9rico,  y 4) autoinmune, basado en una mayor preValencia de hla de clase ii dqw1 y en la existencia de autoanticuerpos frente al plexo mient\u00e9rico.  obejtivos: determinar y comparar el porcentaje de individuos con autoanticuerpos frente al plexo de auerbach en pacientes con acalasia y controles sanos. Estudiar las especificidades al\u00e9licas de los genes de clase ii: hla-dr y dq en una muestra amplia de individuos con acalasia y compararlos con un grupo de controles sanos. Determinar en los pacientes con acalasia la posible asociaci\u00f3n entre determinados genes de clase ii: hla-dr y dq y la existencia de autoanticuerpos frente al plexo de auerbach. Valorar las posibles implicaciones de factores demogr\u00e1ficos, cl\u00ednicos o manom\u00e9tricos con la existencia o no de autoanticuerpos contra el plexo de auerbachy determinados genes del hla de clase ii. Intentar caracterizar diferentes subgrupos de pacientes con acalasia en relaci\u00f3n con la presencia de autoanticuerpos contra el plexo de auerbach y su asociaci\u00f3n con determinados genes de clase ii, para establecer en el futuro protocolos y nuevas l\u00edneas de actuaci\u00f3n terap\u00e9uticas en estos pacientes.  material y m\u00e9todos: se incluyeron de forma consecutiva a 100 individuos. De ellos 60 fueron diagnosticados de acalasia (45 cl\u00e1sica y 15 vigorosa) mediante manometr\u00eda esof\u00e1gica, esofagograma baritado y endoscopia alta. Los 40 restantes eran voluntarios sanos. La recogida de los datos cl\u00ednicos, de filiaci\u00f3n y antecedentes personales se realiz\u00f3 mediante la cumplimentaci\u00f3<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Autoanticuerpos frente al plexo de auerbach y hla de clase ii: su papel en la acalasia.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Autoanticuerpos frente al plexo de auerbach y hla de clase ii: su papel en la acalasia. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Juan  Luis Mendoza  Hern\u00e1ndez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel Diaz Rubio Garcia<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: domingo Espinos perez <\/li>\n<li> Pajares Garc\u00eda Jos\u00e9 Mar\u00eda (vocal)<\/li>\n<li>Jos\u00e9 De portugal  alvarez (vocal)<\/li>\n<li>julio De la morena fern\u00e1ndez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Juan Luis Mendoza Hern\u00e1ndez La acalasia es una enfermedad neuromuscular cr\u00f3nica que afecta al es\u00f3fago. Actualmente la [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[2727,35,9,1737,139],"tags":[897,9552,102361,5696,5888,7008],"class_list":["post-39920","post","type-post","status-publish","format-standard","hentry","category-anticuerpos","category-ciencias-de-la-vida","category-ciencias-medicas","category-inmunologia","category-medicina-interna","tag-domingo-espinos-perez","tag-jose-de-portugal-alvarez","tag-juan-luis-mendoza-hernandez","tag-julio-de-la-morena-fernandez","tag-manuel-diaz-rubio-garcia","tag-pajares-garcia-jose-maria"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39920","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=39920"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/39920\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=39920"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=39920"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=39920"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}