{"id":39947,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-del-tratamiento-con-ly-117018-hc1-o-con-estrogenos-en-un-modelo-experimental-de-osteoporosis-postmenopausica-en-ratas\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efecto-del-tratamiento-con-ly-117018-hc1-o-con-estrogenos-en-un-modelo-experimental-de-osteoporosis-postmenopausica-en-ratas","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-del-tratamiento-con-ly-117018-hc1-o-con-estrogenos-en-un-modelo-experimental-de-osteoporosis-postmenopausica-en-ratas\/","title":{"rendered":"Efecto del tratamiento con ly 117018 hc1 o con estrogenos en un modelo experimental de osteoporosis postmenopausica en ratas."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Calero Anguita Jes\u00fas Antonio <\/strong><\/h2>\n<p>En los \u00faltimos a\u00f1os se ha producido un importante esfuerzo por parte de los investigadores para desarrollar nuevos f\u00e1rmacos que tuvieran las acciones positivas sobre el hueso, pero que no tuvieran los efectos secundarios sobre el \u00fatero o la mama. antes de proceder a la utilizaci\u00f3n de los mismos en humanos son necesarias investigaciones a nivel b\u00e1sico y experimental. el objetivo de esta tesis es precisamente estudiar comparativamente los efectos de un nuevo derivado del raloxifeno, el ly 117018 hc1 y del etinil estradiol sobre el hueso a nivel de masa \u00f3sea y sobre el \u00fatero, en la rata ooforectomizada, modelo experimental de osteoporosis postmenopa\u00fasica. Para la realizaci\u00f3n de este trabajo, se ha manejado un importante n\u00famero de animales, tanto ooforectomizados como controles, y se ha utilizado la t\u00e9cnica de densitometr\u00eda adaptada a las medidas de la rata, puesta a punto previamente por nuestro grupo de trabajo. Por otra parte, algunos de los marcadores de remodelado utilizados espec\u00edficos para ratas, como el telop\u00e9ptido carboxiterminal del col\u00e1geno tipo i, no hab\u00edan sido utilizados anteriormente en este tipo de investigaciones. las conclusiones del presente estudio, prueban que el nuevo derivado del raloxifeno ly 117018 hc1 administrado a las ratas ooforectomizadas, evita en las mismas el desarrollo de la osteoporosis, de modo an\u00e1logo el etinil estradiol, no produci\u00e9ndose los efectos indeseables de hipertrofia uterina de \u00e9ste \u00faltimo.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto del tratamiento con ly 117018 hc1 o con estrogenos en un modelo experimental de osteoporosis postmenopausica en ratas.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto del tratamiento con ly 117018 hc1 o con estrogenos en un modelo experimental de osteoporosis postmenopausica en ratas. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Calero Anguita Jes\u00fas Antonio <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Manuel D\u00edaz Curiel<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: mercedes Alonso bedate <\/li>\n<li>aurelio Rapado errazti (vocal)<\/li>\n<li> Gala paniagua Jos\u00e9 Luis (vocal)<\/li>\n<li>Fernando Marin diez (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Calero Anguita Jes\u00fas Antonio En los \u00faltimos a\u00f1os se ha producido un importante esfuerzo por parte de [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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