{"id":3998,"date":"1994-01-01T00:00:00","date_gmt":"1994-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/1994\/01\/01\/metodologia-para-el-estudio-del-oncogen-her-2-neu-en-cancer-de-mama-correlacion-con-parametros-clinicos-y-con-receptores-de-estradiol-y-progesterona\/"},"modified":"1994-01-01T00:00:00","modified_gmt":"1994-01-01T00:00:00","slug":"metodologia-para-el-estudio-del-oncogen-her-2-neu-en-cancer-de-mama-correlacion-con-parametros-clinicos-y-con-receptores-de-estradiol-y-progesterona","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/quimica\/metodologia-para-el-estudio-del-oncogen-her-2-neu-en-cancer-de-mama-correlacion-con-parametros-clinicos-y-con-receptores-de-estradiol-y-progesterona\/","title":{"rendered":"Metodolog\u00eda para el estudio del oncogen her-2\/neu en cancer de mama: correlacion con parametros clinicos y con receptores de estradiol y progesterona"},"content":{"rendered":"<h2>Tesis doctoral de <strong> Josefa Pilar Fernandez Valeron <\/strong><\/h2>\n<p>Se desarrolla un metodo basado en la pcr diferencial para estimar el numero de copias genicas del oncogen her-2\/neu y se aplica al estudio de 415 canceres de mama invasivos.  el 15% de esos tumores mostraron el oncogen amplificado.  los datos de amplificacion genica fueron comparados con los obtenidos mediante elisa sobre los niveles cuantitativos de expresion de la oncoproteina codificada por dicho oncogen, la p185her-2\/neu, encontrandose una elevada correlacion. A partir de esa alta asociacion se establecio un nivel de expresion de 250 fmol\/mg proteina como punto de corte fiable a partir del cual considerar como sobreexpresada a la p185her-2\/neu. Los datos cuantitativos sobre la expresion de la p185her-2\/neu fueron validados mediante western blot. En muestras seleccionadas se estudio mediante western blot y un anticuerpo antifosfotirosina el estado de fosforilacion de la p185her-2\/neu. La alta asociacion encontrada entre la amplificacion genica del her-2\/neu, la expresion cuantitativa de su oncoproteina y el estado de fosforilacion de la misma, permitio concluir que, al menos en el cancer de mama, la amplificacion genica de este oncogen conduce a su sobreexpresion y que la sobreexpresion de la p185her-2\/neu conlleva la activacion de la oncoproteina. En el estudio de la relacion entre el estado de activacion del her-2\/neu y los factores pronostico se observo que la activacion del oncogen se asociaba con el mayor tama\u00f1o tumoral, la menor edad de la paciente y la ausencia de receptores de estrogenos, progesterona o ambos. La clasificacion de las pacientes en base al estado de afectacion axilar permitio observar que la asociacion negativa de la activacion del her-2\/neu con el contenido en receptores hormonales estaba limitada a las pacientes sin adenopatia axilar.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Metodolog\u00eda para el estudio del oncogen her-2\/neu en cancer de mama: correlacion con parametros clinicos y con receptores de estradiol y progesterona<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Metodolog\u00eda para el estudio del oncogen her-2\/neu en cancer de mama: correlacion con parametros clinicos y con receptores de estradiol y progesterona <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Josefa Pilar Fernandez Valeron <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Palmas de gran canaria<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1994<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Diaz Chico Juan  Carlos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Bonifacio Nicol\u00e1s Diaz Chico <\/li>\n<li>Manuel Morales Gonzalez (vocal)<\/li>\n<li>\u00c1lvaro Ruibal Morell (vocal)<\/li>\n<li>Jos\u00e9 Aguiar Morales (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Josefa Pilar Fernandez Valeron Se desarrolla un metodo basado en la pcr diferencial para estimar el numero [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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