{"id":40015,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/retinoblastoma-en-el-lactante\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"retinoblastoma-en-el-lactante","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/retinoblastoma-en-el-lactante\/","title":{"rendered":"Retinoblastoma en el lactante."},"content":{"rendered":"<h2>Tesis doctoral de <strong>  Paz Gago M. Alejandra <\/strong><\/h2>\n<p>Se realiza un trabajo de investigaci\u00f3n cl\u00ednica sobre el retinoblastoma en el lactante. para ello se ha recogido en los archivos de tres hospitales madrile\u00f1os (cl\u00ednico de san carlos, 12 de octubre y fundaci\u00f3n jimbenez d\u00edaz) las cuarenta historias cl\u00ednicas de los ni\u00f1os ingresados con este tipo de tumor ocular cong\u00e9nito, en el periodo de tiempo que va desde enero de 1978 a diciembre de 1996.  se hace un meticuloso y detallado estudio de los signos cl\u00ednico, entre los que se destacan la leucocoria y el estrabismo como s\u00edntomas m\u00e1s precoces y significativos. En la exploraci\u00f3n oftalmol\u00f3gica se ven masas de coloraci\u00f3n blanquecina y gris\u00e1cea, desprendimiento de retina, hemorragias y necrosis.  se realizan an\u00e1lisis de laboratorio, donde en tres casos se encuentran c\u00e9lulas tumorales en lcr e infiltraci\u00f3n bl\u00e1stica en m\u00e9dula \u00f3sea en cuatro.  las ecograf\u00edas oculares muestran la ocupaci\u00f3n de la c\u00e1mara v\u00edtrea, total o parcial, por una masa hiperecog\u00e9nica.  la afg muestra tiempos vasculares retardados y llamativa tortuosidad vascular.  en el tac y rmn se apreciaron zonas de alta densidad en el globo ocular afecto, mostrando aparici\u00f3n de dep\u00f3sitos de calcio.  los examenes anatomopatol\u00f3gicos macrosc\u00f3picos evidencian masas irregulares, blanquecinas y con aspecto de coliflor. En el examen microsc\u00f3pico, abundante celularidad at\u00edpica, \u00abretinoblastos\u00bb agrupados en rosetas de flexner-wintersteiner.  los cariotipos detectan en alg\u00fan caso deleci\u00f3n del brazo largo del cromosoma 13 y translocaci\u00f3n balanceada en progenitos. Los estudios de gen\u00e9tica molecular revelan la existencia de mutaciones y la presencia del gen rb-1 del retinoblastoma, de ah\u00ed la importancia de los antecedentes familiares y del consejo gen\u00e9tico.  se analizan los tratamientos realizados y se valoran los resultados, as\u00ed como la evoluci\u00f3n de los cuarenta casos de la serie, en la que se curaron veintinueve ni\u00f1os (72,5%), se desconoce<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Retinoblastoma en el lactante.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Retinoblastoma en el lactante. <\/li>\n<li><strong>Autor:<\/strong>\u00a0  Paz Gago M. Alejandra <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Paz Garnelo Jos\u00e9 Antonio<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: julian Garcia sanchez <\/li>\n<li>eduardo Garcia poblete (vocal)<\/li>\n<li>mercedes Bernacer borja (vocal)<\/li>\n<li>alfonso Delgado rubio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Paz Gago M. Alejandra Se realiza un trabajo de investigaci\u00f3n cl\u00ednica sobre el retinoblastoma en el lactante. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[155,9,988,161],"tags":[12926,20539,756,5402,102529,32249],"class_list":["post-40015","post","type-post","status-publish","format-standard","hentry","category-ciencias-clinicas","category-ciencias-medicas","category-oftalmologia","category-pediatria","tag-alfonso-delgado-rubio","tag-eduardo-garcia-poblete","tag-julian-garcia-sanchez","tag-mercedes-bernacer-borja","tag-paz-gago-m-alejandra","tag-paz-garnelo-jose-antonio"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40015","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40015"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40015\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40015"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40015"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40015"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}