{"id":40033,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/produccion-local-de-citoquinas-y-otros-mediadores-de-la-inflamacion-en-pacientes-con-infeccion-abdominal\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"produccion-local-de-citoquinas-y-otros-mediadores-de-la-inflamacion-en-pacientes-con-infeccion-abdominal","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/produccion-local-de-citoquinas-y-otros-mediadores-de-la-inflamacion-en-pacientes-con-infeccion-abdominal\/","title":{"rendered":"Produccion local de citoquinas y otros mediadores de la inflamacion en pacientes con infeccion abdominal."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Joaquin Calatayud Gastardi <\/strong><\/h2>\n<p>La producci\u00f3n y los efectos de las citoquinas se consideran generalmente confinadas a los compartimentos org\u00e1nicos donde son sintetizados. en la peritonitis los efectos del tnfalfa deber\u00edan ser m\u00e1s aparentes en la cavidad peritoneal que en otra parte. Por otro lado, cada vez es m\u00e1s evidente que la s\u00edntesis del \u00f3xido n\u00edtrico (no) y mon\u00f3xido de carbono (co) pueden mediar algunos de los efectos del tnfalfa durante la inflamaci\u00f3n. En este trabajo hemos investigado la posible producci\u00f3n local de citoquinas y otros mediadores de la inflamaci\u00f3n y si existe una fuga sist\u00e9mica desde la cavidad peritoneal en estas condiciones. Para ello se han obtenido simult\u00e1neamente muestras de plasma y l\u00edquido peritoneal de 30 pacientes que han sido sometidos a cirug\u00eda por peritonitis aguda.  el grupo control consisti\u00f3 en 11 pacientes operados por cuadro abdominal agudo, pero sin infecci\u00f3n peritoneal. Las muestras se centrifugaron y se almacenaron a -80grados c hasta el momento de la determinaci\u00f3n de tnfalfa, stnf-r 60 y 80, il-1beta, il-6 (elisa), mn sod (elisa), mpo (espectrofotometr\u00eda), no (reacci\u00f3n de griess), cgmp (ria), co y pla2. Hemos encontrado en el l\u00edquido poeritoneal niveles aumentados de tnfalfa (214.4 +\/- 32.1 vs 37.7 +\/- 33.4 pg\/ml, p&lt;0.01), stnf-r 60 (25.6 +\/- 2.3 vs 9.4 +\/- 3.3 ng\/ml, p&lt;0.01), il-1beta (141.1 +\/- 25.8 vs 44.9 +\/- 9.8 pg\/ml, p&lt;0.01), mpo (19.8 +\/-2.2 vs 9.2 +\/-2.3 mu\/ml, p&lt;0.01), no (18.4 +\/- 2.9 vs 9.4 +\/- 1.0 nmol\/ml, p&lt;0.01), co (70.6 +\/- 1.7 vs 32.9 +\/- 1.5 megamol\/ml, p&lt;0.01) y cgmp (159k +\/- 0.4 vs 12.5 +\/- 0.8 pmol\/ml, p&lt;0.01) comparando con el grupo de pacientes control. Por el contrario s\u00f3lo hemos encontrado en el plasma del grupo de pacientes con peritonitis niveles de tnfalfa (48.2 +\/- 9.4 vs 7.7 +\/- 1.9 pg\/ml, p&lt;0.01) y de cgmp (30.7 +\/- 1.0 vs 26.3 +\/- 1.5 pmol\/ml, p&lt;0.01) estad\u00edsticamente signicativos. Concluimos que en la peritonitis humana hay un aument<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Produccion local de citoquinas y otros mediadores de la inflamacion en pacientes con infeccion abdominal.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Produccion local de citoquinas y otros mediadores de la inflamacion en pacientes con infeccion abdominal. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Joaquin Calatayud Gastardi <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 Complutense de Madrid<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Luis Balibrea  Cantero<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Jaime Arias perez <\/li>\n<li>Elena Vara ameigeiras (vocal)<\/li>\n<li>Miguel angel Ca\u00ednzos fern\u00e1ndez (vocal)<\/li>\n<li>Francisco Sanchez lozano (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Joaquin Calatayud Gastardi La producci\u00f3n y los efectos de las citoquinas se consideran generalmente confinadas a los 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