{"id":40095,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-la-dinamica-de-las-citocinas-sericas-en-la-brucelosis-humana\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-la-dinamica-de-las-citocinas-sericas-en-la-brucelosis-humana","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-la-dinamica-de-las-citocinas-sericas-en-la-brucelosis-humana\/","title":{"rendered":"Estudio de la dinamica de las citocinas sericas en la brucelosis humana."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Marcial Delgado Fernandez <\/strong><\/h2>\n<p>Objetivo: conocer el comportamiento s\u00e9rico del factor de necrosis tumoral alfa, de la interleucina 1 alfa, de la interleucina 6 y del interfer\u00f3n gamma en pacientes diagnosticados de brucelosis, seguidos al diagn\u00f3stico, al final del tratamiento y al final del periodo de seguimiento (6 meses).  resultados: tanto en los pacientes como en los controles no se detectaron niveles superiores a 10 pg\/ml al diagn\u00f3stico, al final del tratamiento o al final del seguimiento. los pacientes presentaron il-1 alfa superiores en un 19.3% de los casos, con respecto a los controles (3%). Los pacientes con esplenomegalia presentaban superiores a 10 pg\/ml en un porcentaje significativamente superior. Los niveles superiores a 10 pg\/ml presentaban niveles significativamente superiores de interfer\u00f3n gamma circulante. La persistencia de niveles de il-1 alfa se asociaba a antecedentes de formas o desarrollo de formas complicadas o cuadros articulares reactivos. No detectamos ascensos significativos en los pacientes con respecto a los controles con respecto a los niveles s\u00e9ricos de il-6 (22.3 versus 13% con valores superiores a 10 pg\/ml). El 50.6% de los pacientes presentaron niveles s\u00e9ricos superiores a 10 pg\/ml, frente al 25% de los controles. Los pacientes m\u00e1s j\u00f3venes y los con menor demora diagn\u00f3stica produc\u00edan significativamente niveles de ifn gamma superiores a 10 pg\/ml. Los niveles s\u00e9ricos elevados de ifn gamma se asocian significativamente a una mayor presencia de esplenomegalia, y se correlacionan de forma inversa con el contaje de leucocitos totales. Los niveles s\u00e9ricos se normalizan con la respuesta al tratamiento. Las recaidas se asocian a nuevas elevaciones de los niveles de ifn-gamma.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de la dinamica de las citocinas sericas en la brucelosis humana.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de la dinamica de las citocinas sericas en la brucelosis humana. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Marcial Delgado Fernandez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li> Alonso Colmenero A. J.<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: Miguel Morell oca\u00f1a <\/li>\n<li>Carlos Juarez fernandez (vocal)<\/li>\n<li>Jos\u00e9 Pe\u00f1a Martinez (vocal)<\/li>\n<li>Manuel Santamaria ossorio (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Marcial Delgado Fernandez Objetivo: conocer el comportamiento s\u00e9rico del factor de necrosis tumoral alfa, de la interleucina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[35,9,1085,1737,2612,7834,139],"tags":[102682,22212,13,22188,102681,2167],"class_list":["post-40095","post","type-post","status-publish","format-standard","hentry","category-ciencias-de-la-vida","category-ciencias-medicas","category-enfermedades-infecciosas","category-inmunologia","category-inmunoquimica","category-malaga","category-medicina-interna","tag-alonso-colmenero-a-j","tag-carlos-juarez-fernandez","tag-jose-pena-Martinez","tag-manuel-santamaria-ossorio","tag-marcial-delgado-fernandez","tag-miguel-morell-ocana"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40095","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40095"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40095\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40095"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40095"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40095"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}