{"id":40099,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/estudio-de-las-interacciones-farmacologicas-de-zidovudina-con-farmacos-inductores-del-metabolismo-hepatico-y-su-toxicidad\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"estudio-de-las-interacciones-farmacologicas-de-zidovudina-con-farmacos-inductores-del-metabolismo-hepatico-y-su-toxicidad","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/estudio-de-las-interacciones-farmacologicas-de-zidovudina-con-farmacos-inductores-del-metabolismo-hepatico-y-su-toxicidad\/","title":{"rendered":"Estudio de las interacciones farmacologicas de zidovudina con farmacos inductores del metabolismo hepatico y su toxicidad."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Teresa Fuentes Lopez <\/strong><\/h2>\n<p>El objetivo del presente trabajo ha sido evaluar las posibles modificaciones en la toxicidad hematologica por azt en ratones cd1 tratados de forma combinada con azt y farmacos inductores del metabolismo hepatico. Previa obtencion de un modelo de toxicidad hematologica, se dise\u00f1aron 6 grupos de tratamiento que recibieron suero fisiologico, suero glucosado, azt mas rifampicina, azt mas dexametosona, rifampicina y dexametasona, se determinaron parametros hematrimetricos, niveles plasmaticos del farmaco y su metabolito conjugado, asi como cantidad de citocromo p450 y las actividades reductasas. En nuestro modelo experimental ex vivo el azt muestra una toxicidad hematologica progresiva en relacion con la duracion del tratamiento. La administracion de farmacos inductores se tradujo en un incremento del metabolismo hepatico, puesto de manifiesto por un incremento de citocromos p450. La administracion de forma combinada de azt y farmacos inductores se tradujo en una disminucion de la toxicidad del farmaco antirretroviral. Concluimos que la toxicidad hematologica por azt se debe fundamentalmente a la accion del propio farmaco y no de su metabolito reducido amt.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Estudio de las interacciones farmacologicas de zidovudina con farmacos inductores del metabolismo hepatico y su toxicidad.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Estudio de las interacciones farmacologicas de zidovudina con farmacos inductores del metabolismo hepatico y su toxicidad. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Teresa Fuentes Lopez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>Jos\u00e9 Antonio Gonz\u00e1lez Correa<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: rafael Martinez sierra <\/li>\n<li>baldomero Lara romero (vocal)<\/li>\n<li>m isabel Lucena gonzalez (vocal)<\/li>\n<li> Gavilan carrasco Juan  Carlos (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Teresa Fuentes Lopez El objetivo del presente trabajo ha sido evaluar las posibles modificaciones en la toxicidad [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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