{"id":40154,"date":"1999-01-01T00:00:00","date_gmt":"1999-01-01T00:00:00","guid":{"rendered":"https:\/\/www.deberes.net\/tesis\/sin-categoria\/efecto-de-la-administracion-prolongada-de-ciclosporina-a-sobre-las-lipoproteinas-plasmaticas-y-consecuencias-sobre-la-distribucion-lipoproteica-un-estudio-experimental\/"},"modified":"1999-01-01T00:00:00","modified_gmt":"1999-01-01T00:00:00","slug":"efecto-de-la-administracion-prolongada-de-ciclosporina-a-sobre-las-lipoproteinas-plasmaticas-y-consecuencias-sobre-la-distribucion-lipoproteica-un-estudio-experimental","status":"publish","type":"post","link":"https:\/\/www.deberes.net\/tesis\/ciencias-medicas\/efecto-de-la-administracion-prolongada-de-ciclosporina-a-sobre-las-lipoproteinas-plasmaticas-y-consecuencias-sobre-la-distribucion-lipoproteica-un-estudio-experimental\/","title":{"rendered":"Efecto de la administracion prolongada de ciclosporina a sobre las lipoproteinas plasmaticas y consecuencias sobre la distribucion lipoproteica. un estudio experimental."},"content":{"rendered":"<h2>Tesis doctoral de <strong> Ramiro Alcantara Benitez <\/strong><\/h2>\n<p>Estudio experimental en ratas wistar macho, 6 campos de 10 animales cada uno, administrando csa a dosis de 10 mgr\/kg\/d durante 15, 30 y 45 d\u00edas y cremophore e1 a la misma dosis durante el mismo tiempo.  objetivos: determinar en un modelo experimental si la csa induce modificaciones en los l\u00edpidos y lipopreote\u00ednas plasm\u00e1ticas, en relaci\u00f3n al tiempo de tratamiento. Comprobar si estas posibles modificaciones causan un cambio en la distribuci\u00f3n lipoprote\u00edca de la csa \u00abin vivo\u00bb. explorar si estas modificaciones tienen alg\u00fan impacto sobre par\u00e1metros de toxicidad.  conclusiones: se detecta una elevaci\u00f3n del colesterol plasm\u00e1tico homog\u00e9nea e independiente del tiempo de tratamiento; y una disminuci\u00f3n de los triglic\u00e9ridos plasm\u00e1ticos, posiblemente por la anorexia y desnutrici\u00f3n que produce el f\u00e1rmaco. En vldl se produce un incremento no lineal del colesterol. De igual modo aument\u00f3 homog\u00e9neamente el colesterol ldl y disminuyeron los triglic\u00e9ridos en esta fracci\u00f3n. En ambos casos parece deberse a efecto directo sobre el h\u00edgado, del f\u00e1rmaco.  se detect\u00f3 una disminuci\u00f3n de la masa lip\u00eddica total en hdl2 y un aumento paralelo en hdl3, parece debido a inhibici\u00f3n de lpl y lcat.  al alargar el tiempo de tratamiento la csa se asocia a hdl, fundamentalmente a hdl3 (disminuyendo en hdl2). Estos cambios se correlacionan a cambios en la composici\u00f3n lip\u00eddica de las liporote\u00ednas.<\/p>\n<p>&nbsp;<\/p>\n<h3>Datos acad\u00e9micos de la tesis doctoral \u00ab<strong>Efecto de la administracion prolongada de ciclosporina a sobre las lipoproteinas plasmaticas y consecuencias sobre la distribucion lipoproteica. un estudio experimental.<\/strong>\u00ab<\/h3>\n<ul>\n<li><strong>T\u00edtulo de la tesis:<\/strong>\u00a0 Efecto de la administracion prolongada de ciclosporina a sobre las lipoproteinas plasmaticas y consecuencias sobre la distribucion lipoproteica. un estudio experimental. <\/li>\n<li><strong>Autor:<\/strong>\u00a0 Ramiro Alcantara Benitez <\/li>\n<li><strong>Universidad:<\/strong>\u00a0 M\u00e1laga<\/li>\n<li><strong>Fecha de lectura de la tesis:<\/strong>\u00a0 01\/01\/1999<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h3>Direcci\u00f3n y tribunal<\/h3>\n<ul>\n<li><strong>Director de la tesis<\/strong>\n<ul>\n<li>P. Gonzalez Santos<\/li>\n<\/ul>\n<\/li>\n<li><strong>Tribunal<\/strong>\n<ul>\n<li>Presidente del tribunal: salvador Gonzalez baron <\/li>\n<li>Javier Salmeron escobar (vocal)<\/li>\n<li>Jos\u00e9 Antonio Jim\u00e9nez perep\u00e9rez (vocal)<\/li>\n<li>eduardo Franquelo villalonga (vocal)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Tesis doctoral de Ramiro Alcantara Benitez Estudio experimental en ratas wistar macho, 6 campos de 10 animales cada uno, administrando [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-gradient":""}},"footnotes":""},"categories":[9,189,218,7834,139,17648],"tags":[24706,2071,1614,102766,102765,17975],"class_list":["post-40154","post","type-post","status-publish","format-standard","hentry","category-ciencias-medicas","category-farmacodinamia","category-hematologia","category-malaga","category-medicina-interna","category-procesos-metabolicos-de-los-farmacos","tag-eduardo-franquelo-villalonga","tag-javier-salmeron-escobar","tag-jose-antonio-jimenez-pereperez","tag-p-gonzalez-santos","tag-ramiro-alcantara-benitez","tag-salvador-gonzalez-baron"],"_links":{"self":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40154","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/comments?post=40154"}],"version-history":[{"count":0,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/posts\/40154\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/media?parent=40154"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/categories?post=40154"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.deberes.net\/tesis\/wp-json\/wp\/v2\/tags?post=40154"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}